DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7470 and alh-13

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_510132.2	Gene:	alh-13 / 181417	WormBaseID:	WBGene00011938	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	737	Identity:	411/737 - (55%)
Similarity:	542/737 - (73%)	Gaps:	20/737 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RLEKAHPTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLEGREVMMVTS 103
            :..:.||....|:.||.|:|:|||||||||||||..||||||||||||||:|....||::::|:|
Worm    64 KTRQKHPLINTRNDLKKAQRVVVKLGSAVITREDECGLALGRLASIVEQVSELQQSGRQMLIVSS 128

  Fly   104 GAVAFGKQKLAQELLMSLSMRETLNPKDSKEFDGATLEPRAAAAVGQSGLMSLYDAMFAQYGVKI 168
            ||||||:|||.|||:||:|||:||...     .|.|.:.||.||.|..||||||:.:|.|||:.:
Worm   129 GAVAFGRQKLRQELVMSMSMRQTLRGP-----SGMTADKRACAASGMPGLMSLYEQLFQQYGITV 188

  Fly   169 AQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINTNDAVSPPMFIRDDEPAGGARRGIPIKDN 233
            ||||:||||..:::.|.||..|:..|:||||:||:|.||||:|       :|    :..:.|.||
Worm   189 AQVLLTKPDIDDDQRRKNLQATIESLLSLNIIPIVNANDAVAP-------DP----KLNMHISDN 242

  Fly   234 DSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGAKLMHTYTSDDSNSIEFGKKSKVGTGGMDSK 298
            |||:|.|:||::|:|||::|:|:|:|..||..:|::|::||...:::.:.||..||.|||||:||
Worm   243 DSLAARLSAEIEAELLIILSNVNGVYTGPPDLEGSRLLYTYVPSENSGVTFGANSKFGTGGMESK 307

  Fly   299 VKAATWALDRGVSVVICNGMQEKAIKTIIGGRKVGTFFTEATESANAVPVEVMAENARTGSRQMQ 363
            |.|...||:.||:.||.||:.:.||...:.|:|:||.|.. |:.....|:|.:||..|...||:.
Worm   308 VTACVNALNNGVTTVITNGLAQDAITDAVAGKKIGTMFCN-TKGYEGPPIEEVAEKCRDAGRQLA 371

  Fly   364 ALTPAQRASAVNTLADLLVSREKFILDANAKDLAEAQKSGLAKPLLSRLSLNPAKLKNLSVGLKQ 428
            ||:..:|.:.|..||.|||.:||:|::||..|||.|:.:||...||:||.:.|.|:::|..||..
Worm   372 ALSNKERGAMVRHLAALLVDKEKYIIEANQTDLANAKSAGLDPQLLNRLKMTPEKIQDLHAGLNT 436

  Fly   429 IAEDSHKNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDSLPQVAALAMASANGLLLKGGK 493
            ||:.:...|||||::.::::.|.|:|||||||.|:||||||||.|||||:|||||.|.|||||||
Worm   437 IADSAETLVGRVLKKVKISEGLFLEQVTVPIGSLMVIFESRPDCLPQVASLAMASGNALLLKGGK 501

  Fly   494 EAAHSNKALMELVKEALATVGAE--HAVSLVSTREEISDLLSMENHIDLIIPRGSSDLVRSIQQQ 556
            ||..|||||..||:|||.|.|.|  .||:||.:||:::|||.:::.|||||||||||||||:|::
Worm   502 EAEESNKALHALVQEALGTHGFEMRDAVTLVRSREDVADLLQLKDLIDLIIPRGSSDLVRSMQEK 566

  Fly   557 SLHIPVLGHAEGVCHVYIDRDADLEKALRIARDAKCDYPAACNAMETLLIHEDLMSGAIFGDVCN 621
            |..||||||||||||||||:|.|.:||::|.||:|||||:||||.||:|||:||.:...|..:|:
Worm   567 SKGIPVLGHAEGVCHVYIDKDCDEQKAIQIVRDSKCDYPSACNAAETILIHKDLATAPFFDSLCS 631

  Fly   622 MLKREGVKIYAGPRLNQQLTFGPPAAKSLKHEYGALECCIEVVPSLDEAINHIHTYGSSHTDVIV 686
            |.|.||||::|||:|...|.|.||.|:|:..|||:|||.:|||.:::||:.||..|||.||:.|:
Worm   632 MFKAEGVKLHAGPKLAALLKFAPPPAESMSFEYGSLECTLEVVDNVEEAVAHIIRYGSGHTESII 696

  Fly   687 TENDAAARQFLGSVDSACVFHNASSRFADGFRFGLGAEVGISTARIHARGPVGVEGLLTTKWILE 751
            |||...|..||..|||||.|||||:|||||:||||||||||||.||||||||||||||||||:|.
Worm   697 TENTNTAEHFLKHVDSACAFHNASTRFADGYRFGLGAEVGISTGRIHARGPVGVEGLLTTKWLLR 761

  Fly   752 GQDHAAADFAEGGGRTWLHETL 773
            |:.|...|| :.|..::|||.|
Worm   762 GEGHLVEDF-KNGKYSYLHENL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789	150/287 (52%)
		P5CS	50..775	CDD:130164	409/726 (56%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	247/405 (61%)
alh-13	NP_510132.2	AAK_P5CS_ProBA	74..346	CDD:239789	150/287 (52%)
		P5CS	75..782	CDD:130164	408/724 (56%)
		ALDH_F18-19_ProA-GPR	357..763	CDD:143398	247/405 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162170
Domainoid	1	1.000	313	1.000	Domainoid score	I704
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2142
Inparanoid	1	1.050	793	1.000	Inparanoid score	I256
Isobase	1	0.950	-	0.975504	Normalized mean entropy	S1064
OMA	1	1.010	-	-		QHG58163
OrthoDB	1	1.010	-	-		D832430at2759
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto17734
orthoMCL	1	0.900	-	-		OOG6_101419
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R982
SonicParanoid	1	1.000	-	-		X2479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890