Protein Alignment Chs2 and chs1

DIOPT Version :10

• Sequence 1: NP_524209.3
• Gene: Chs2 / 40442
• FlyBaseID: FBgn0029091
• Length: 1393
• Species: Drosophila melanogaster
• Sequence 2: NP_001303255.1
• Gene: chs1 / 322468
• ZFINID: ZDB-GENE-030131-1188
• Length: 1463
• Species: Danio rerio
• Alignment Length: 1552
• Identity: 440/1552 - (28%)
• Similarity: 654/1552 - (42%)
• Gaps: 494/1552 - (31%)

  Fly    14 RSRKQRDKPSLWDSFQDPPSKKTSGSDADWKKLQFCLKLFKICTYLLVFAVVLATSVFA--NLIY 76
            |..:.||   .||.||..|      ..|:.:|.|.|.::.:....:||...||.:.|.:  :|:.
Zfish    11 REGRHRD---TWDPFQLNP------IGAEKEKKQVCFRILQNLVAVLVGLAVLVSGVVSKGSLLV 66

  Fly    77 LYMAGNTGGTGPRVQVCSKYPVLRHGQVEAVASELDQIAWVWALIFAFAAPELLTFLRALRICMF 141
            |     |...||:                ::..|::|..:...|:.....|.||.||:||..|:|
Zfish    67 L-----TTLAGPK----------------SLRDEVEQQFYGLLLMCVLVTPNLLMFLKALWKCVF 110

  Fly   142 KREQRPSGLEVGLVTLFELLHVVGLALLTFTVLPALDVTRGAILGCCVCFVPALLNLL--TGTRV 204
            |....|:...:|:|...|.|..:|.|:|...|:|.||:.....:...:|...|:|.:.  ..||
Zfish   111 KSYVAPNPRTLGIVCGIEALVALGTAMLVLIVMPNLDILTNLCIPGGICIFSAVLQIAFRLQTR- 174

  Fly   205 RWRSADSLVLGLSILALVAQGSVFLVW-----------PSLSDSME----------VQLLAIPLL 248
            ||    .::..:..|.||..| .||:.           ...||.:|          |.:.....|
Zfish   175 RW----MILYPICSLILVVSG-YFLLGIDYYVREKTYIKHFSDRLENVDDYMTYVYVGIAIFASL 234

  Fly   249 LISFRWWEN----FANTHEAIAYIIRTIRCTRSRYHTYLYLAPLKVLVFAGMGFILHGHEFVEYF 309
            |:|..||||    ..|..|.::. :.|.|.|     .|::.:.::::|...:.|:        ||
Zfish   235 LVSLNWWENPFQASTNIQEMLSE-LDTFRDT-----AYVFTSFIRIVVTLAVYFL--------YF 285

  Fly   310 GRFRDAWRPHLITLVQSNGDPDALLLA-QANVSITAPPRRTLFTMQSSPNSVFYALAAQVGAAYL 373
                       ..:..:..:.||...| ||...|..    .||.:|:      :..||
Zfish   286 -----------FVIANNQFEWDAYTKASQATQEIAL----GLFFLQA------FCSAA------- 322

  Fly   374 CHIFGKFACKIKIQKFSYALPLSLAGPATVCL--VTFLAQLRASDPCSLHGFMPDYLSLLALGGS 436
            ||.||..||||...||.:|||:||.||||:.|  :.|:.|....:|      .|:..:::. |..
Zfish   323 CHWFGVVACKIHAMKFGFALPVSLIGPATLILGMILFVTQSAQFNP------SPEIAAIIK-GNI 380

  Fly   437 VEELGQRC------------------LDYALW---------LWPL---------WWLAQVWTCLH 465
            ..:....|                  :.|::.         :||.         .|||.|....:
Zfish   381 TNDFWPFCYELKSLSDVNTTPVVMLEISYSICKTSLNNPYEMWPFSMLALEGVCMWLALVSCTYY 445

  Fly   466 IWQPHNDRNAPTEKLFVCPWYCGLLVDQCSMMNRRIVDWSEEYLAIKSDLTAPRDPVVALAADIN 530
            ||:....|...|..|||...|....:|...::|.:          :|...||.|:
Zfish   446 IWKIKVQRIERTSLLFVRRLYESAFIDISMLLNTK----------MKVIRTANRE---------- 490

  Fly   531 ASRDIQEEDKVPQLIVCATMWHETEDEMMEFLKSIVRLDEDQCARRMARTHLNGGKADDEY---Y 592
            ::.|.:.|:.|  :.:||||||||.|||::.|.|:.|||..:            |...:|:   :
Zfish   491 SNNDAELENCV--IYLCATMWHETYDEMLKILTSMFRLDRYR------------GDPKEEHKDCF 541

  Fly   593 ELETNIFFDDAFVSDPRQCQNKRNPPINEYVKTLTRTIDKAAFEVYGVNIRIKPP--LKIETPYG 655
            :.|.:|:.||||:.:    ::.....:|.||:.|...:    .|||.|....:|.  ..||||||
Zfish   542 DFECHIYVDDAFMIE----KDSGTKFVNTYVEDLIHVV----MEVYRVFTNKEPDEVSIIETPYG 598

  Fly   656 GRLVWTLPGRTKMVAHLKNKDKIRHKKRWSQVMYMYYLL---GYRIME----TKELSPRRKAVIA 713
            ||||:.:|....:..|||:|..||:||||||:||:||||   ||.:..    |::.:|.|.::::
Zfish   599 GRLVFVMPEGNMLYVHLKDKQLIRNKKRWSQIMYLYYLLGWKGYNVKNPQKITRQNNPCRASLVS 663

  Fly   714 ----------------------ENTFILALDGDIDFQPRAVRLLIDRMKAVDELGAACGRIHPVG 756
                                  :||:|:|||||.||.|:|:.||:||::..|.:|||||||||.|
Zfish   664 LDSETYLLPGLDNDSKRRHISDDNTYIMALDGDTDFHPKALILLVDRLRMYDNVGAACGRIHPTG 728

  Fly   757 RGPMVWYQRFEYAIGHWLQKATEHVIGCVLCSPGCFSLFRASALMENSVMKRYTMISSEAMKMVQ 821
            .|||||||:||||:||||||..|||.|.||||||||||||.||||:::|:||||..::.|.:.||
Zfish   729 MGPMVWYQKFEYAVGHWLQKTAEHVFGSVLCSPGCFSLFRGSALMDDNVLKRYTTKATRASEYVQ 793

  Fly   822 YDQGEDRWLCTLLLKAGSRVEYCAASDAYTHAPESFNEFYNQRRRWVPSTIANIFDILADADTVV 886
            ||||||||||||||:.|.||||.|||||||::|:.|.|||||||||.|||:||..|:|......|
Zfish   794 YDQGEDRWLCTLLLQQGWRVEYNAASDAYTNSPQEFKEFYNQRRRWGPSTLANTLDLLHSGKETV 858

  Fly   887 KKNNSISTMYVWYQGMLMIGTVLGPGTIFLMMVGALVAVFSIDIWTAFLWNFFPILLFILACVYL 951
            |:|.|||.:|:.||...:..::|||.::.||:.||...||.:....:.:....|.:.::|.|...
Zfish   859 KRNTSISMLYILYQIFTVASSILGPASVTLMIAGAFQFVFGVSGTLSIIIAVIPPVFYMLICFLA 923

  Fly   952 KQKFQLLIAFVISSVYCLVMMAVLIGIIVQMLEDGP-LAPASLFFLLVAVQITIAGFMHPQEFWA 1015
            |...|:.||.::|.:|..:|.|....||..|:..|. :.|..||.:..|:...:...:||||...
Zfish   924 KPNLQITIAAILSVIYAFLMTASFFAIIGDMVIQGTFITPTGLFLVSGAILYMVTAVLHPQECTL 988

  Fly  1016 LLCGVIYYITIPSMYMLLMIFSVFNMNDVSWGTRE------------------------------ 1050
            ::.|::|:|.|||.|:||.|:|:.||:.|||||||
Zfish   989 IIYGLMYFICIPSGYLLLTIYSLVNMHIVSWGTRESTKGKEQKKQVGVVCNRDCRMCCWDVKIQV 1053

  Fly  1051 ------------------------------------APV-------------------------L 1054
                                                ||.                         |
Zfish  1054 TQETENLLLQQMQQAVNPTAAAAAKAEPEEPATLSAAPEHSSVEISRHVQEKNMENKKDQSKENL 1118

  Fly  1055 KDDGK-----------------------------------DAVDEANNY---------------- 1068
            ..|.|                                   |..||..:|
Zfish  1119 NKDNKERDSESERSSSSSSSEKKMDTFNDDTDYEDTDYDDDDDDEDYDYNTVEPKEVVPESAWVE 1183

  Fly  1069 ------------------------------------------LPGWLNDPL-------------- 1077
                                                      |...|||.|
Zfish  1184 PVKREFLKKLTYANLKRNLQEQIRYTLRNKNQEDLCEELVLILTDTLNDELKDKVGPEDVLTETQ 1248

  Fly  1078 ---------------------------------------LIDSELGEVSLMEQRFWKDLIKQYLK 1103
                                                   |:..::.::|..||.||:.|:::|||
Zfish  1249 LEELQYALNEAARRIVKTNRIETGSQRVERRVKRGIERTLVAPQVEKLSEDEQDFWEKLLERYLK 1313

  Fly  1104 PLELSREQKQAMADGLKELRNMIAFAFVMVNAIFVLIVFLLQLKKEFLHLEWPIDPTDFVSFDRD 1168
            |::..:...:.:...||.|||...|.:.::|.::|:..|.||                  :...|
Zfish  1314 PIQDDKAHLEEVTRELKSLRNKAVFLYFIINVLWVVATFFLQ------------------AIGGD 1360

  Fly  1169 NLMVGIYRQYK---------ELDPIGLCFVIFFGLILIIQFLAMFFHRFATLCQLLA 1216
            .|.:.|.:.|.         .::|:.|.|::.|.::|::|||||.:||..||..:::
Zfish  1361 VLSIEIPKYYPNKTLAPEPLRVEPLSLMFLLSFAVLLVVQFLAMLYHRVYTLIHVVS 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chs2	NP_524209.3	Chitin_synth_C	546..874	CDD:133033	179/361 (50%)
		BcsA	<789..976	CDD:440828	93/186 (50%)
		SLC5-6-like_sbd	903..>1055	CDD:444915	54/243 (22%)
chs1	NP_001303255.1	Glyco_tranf_GTA_type	505..846	CDD:472172	179/360 (50%)
		Chitin_synth_2	<689..1035	CDD:367353	175/345 (51%)
		SMC_N	1182..>1333	CDD:481474	18/150 (12%)