DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and SV2A

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001315603.1	Gene:	SV2A / 9900	HGNCID:	20566	Length:	742	Species:	Homo sapiens

Alignment Length:	680	Identity:	133/680 - (19%)
Similarity:	219/680 - (32%)	Gaps:	244/680 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DSPSSVYEEDWLGFTIPKKNSAWDDCHRYA-----ANISDAISGYTDPSG-----------QYCL 138
            |....:||.::.|  ||:..|.... .|.|     |.:...:|....|.|           :...
Human    88 DEDDEIYEGEYQG--IPRAESGGKG-ERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELA 149

  Fly   139 KEYFTITSETCGR-------------------------DFKFRDEEKTISTEFGIYCEDEWKLSM 178
            ::|..|..| ||.                         .|.....||.:       |..:....|
Human   150 QQYEAILRE-CGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDM-------CLSDSNKGM 206

  Fly   179 VGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLD-MAVGS 242
            :|.|..:|..||..|.|..|||.|||..|.::.||:::.....|....|..||....|. :.:|.
Human   207 LGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGG 271

  Fly   243 TLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFL----------------ASQVQHWRW 291
            :: |..|....|.:..::|....:.:.:|:.:|..:...:                |.|...||.
Human   272 SI-PIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRV 335

  Fly   292 LLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPL--PEE--QLNDLLTS 352
            .:.|...|:|..|..|...|||.|:.|..|..::|..||::....|.|..  ||.  .:..:.|.
Human   336 FVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTI 400

  Fly   353 NRQ----KLSQANESQY-----------------------PIMRAVVFFSLRIANCCLCWFTHTL 390
            :::    ::.....:.|                       |..|.:....:.:      |||.:.
Human   401 HQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGV------WFTMSF 459

  Fly   391 IALGLSL------------------------------------NSVNLGGN-------------- 405
            ...||::                                    |.::.||.
Human   460 SYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSV 524

  Fly   406 ----------------------------------------KYTN-------FMLNG--------- 414
                                                    |:.|       |:.|.
Human   525 SFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTG 589

  Fly   415 ---------FIQ-------IPGLLLPLVIMDRVGRRHSLC-ASMLLCAICMGASAAVPADNYAGS 462
                     |:.       :||.::..::||::||...|. :|::.|..|...|.   .::.:..
Human   590 TGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSF---GNSESAM 651

  Fly   463 LALF-LIGKLAITCSFQILYFFTSEIFPTNVRNT----LLSLCSMVGRIGSMLAPQTPLLAKYYI 522
            :||. |.|.::| .|:..|...|.|::|::.|.|    |.:||.:...:|..:......:.|
Human   652 IALLCLFGGVSI-ASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITK--- 712

  Fly   523 YAPQILFATFALISG-FLTLAFPETADKVL 551
             |..||||:.||..| .|.|..|||..:||
Human   713 -AAPILFASAALALGSSLALKLPETRGQVL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	133/680 (20%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	107/559 (19%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	133/680 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..144		13/58 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910