Protein Alignment CG7458 and SLC22A14

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 140/576 - (24%)
• Similarity: 266/576 - (46%)
• Gaps: 85/576 - (14%)

  Fly    34 EDNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSIS--YVFTASTVVHRCTVPQCDSP---- 92
            :|:....:|..:|:||.:|.....|..:|.:.:|||..:  :||||..       |.|::.
Human   129 QDDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQK-------PYCNTSWILA 186

  Fly    93 --SSVYEEDWLGFTIPK-KNSAWDDCHRYAA---NISDAISGYTDPSGQYCLKEYFTITSETCGR 151
              ..:.:.:.|..|||: .|.::..|..|..   |:...|        |:.|.:     ::||..
Human   187 VGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSII--------QFGLND-----TDTCQD 238

  Fly   152 DFKFRDEEK-TISTEFGIYCEDEWKLSMVGTINNVGQFV---GIPLGG----YFADRYGR--RTM 206
            .:.:.|.:| ::..||.:.|..|.|       .:..|.:   |:|:|.    ...|:.||  ..:
Human   239 GWIYPDAKKRSLINEFDLVCGMETK-------KDTAQIMFMAGLPIGSLIFRLITDKMGRYPAIL 296

  Fly   207 LAVAGSVSALMGVIRSLSSNYSMFLVFEF--LDMAVGSTLFPTAFLLAIELVGPKRRVAAATIIT 269
            |::.|.:  :.|...:..:::.::|.|.|  ....||..:  ::..||.|.:..:.|..|..:..
Human   297 LSLLGLI--IFGFGTAFMNSFHLYLFFRFGISQSVVGYAI--SSISLATEWLVGEHRAHAIILGH 357

  Fly   270 IFYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAA 334
            .|:|:|...|..:|..:.||:.|..|.....:..|.::||||||.|||:.:|..::|..||..||
Human   358 CFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAA 422

  Fly   335 RINQRPLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNS 399
            .:|::.:|...|::|... |:|:::|:...:...|.:...:| :.:|  .|||.:.....|||..
Human   423 SVNKKTIPSNLLDELQLP-RKKVTRASVLDFCKNRQLCKVTL-VMSC--VWFTVSYTYFTLSLRM 483

  Fly   400 VNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAI-CM-------GASA---- 452
            ..||.:.:...::...:::|..|..:.::.::||:.||..::|...| |:       |...
Human   484 RELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLK 548

  Fly   453 --AVPADNYAG-SLALFLIGKLAITCSFQILYFFTSEIFPTNVRNT---LLSLCSMVGRIGSM-L 510
              ..||..... ::.:.::.:.::..:..:.:.:|:|:.||.:|.|   |:||.|:.|.|.|: :
Human   549 WPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTI 613

  Fly   511 APQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDL-NQAK 565
            ..|||.|      .|..|....|:::..|:...|||.|:.|..::..:..: |:.|
Human   614 ISQTPSL------LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVK 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	136/550 (25%)
		MFS	161..544	CDD:119392	101/412 (25%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	136/549 (25%)
		MFS	270..641	CDD:119392	95/384 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153812
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950