Protein Alignment CG7458 and SLC22A8

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001171661.1
• Gene: SLC22A8 / 9376
• HGNCID: 10972
• Length: 542
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 145/545 - (26%)
• Similarity: 253/545 - (46%)
• Gaps: 42/545 - (7%)

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTI 105
            ||.|:|..|.:|.::..:|.:|:|..|..::..:|||:|.||.|..|...|..     .|:   :
Human     6 ILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTG-----PWV---L 62

  Fly   106 PK-KNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEEKTISTEFGIY 169
            |. .|...:.|.|:....:.::...|..:.:.||..:.            :...:.:|.||:.:.
Human    63 PMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWV------------YNSTKDSIVTEWDLV 115

  Fly   170 CEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFE 234
            |.......|..:|...|..:|..:.|..:||:|||.:|..:..:.|..|...:.|..:.:::||.
Human   116 CNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR 180

  Fly   235 FL-DMAV-GSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLY 297
            || ...: |.||  :..:|.:|.|..:.|...:|.:...|..|:..|..||..:..||||...:.
Human   181 FLCGFGISGITL--STVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVS 243

  Fly   298 APAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLN-DLLTSNRQKLSQAN 361
            .|..:..|..|..|||:|||:..|...||..:|||.|..|.:....|:|: :.|..|.||.....
Human   244 IPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLA 308

  Fly   362 ESQY--------PIMRAVVFFSLRIANC-CLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQ 417
            :::|        |::|.:.|       | .|.||........|::.....|.|.|...::.|.:.
Human   309 KAKYTASDLFRIPMLRRMTF-------CLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVD 366

  Fly   418 IPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQILYF 482
            :|...:.::.:..:||..:..|::||....:.|...||.|.......|.:.||..::.||..|:.
Human   367 VPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFL 431

  Fly   483 FTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETA 547
            :|||::||.:|.|.:.:.::..|:|||::|...:..:...:.|.|::...||:.|...|..|||.
Human   432 YTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETL 496

  Fly   548 DKVLPTTIEEARDLNQAKRRSERSP 572
            ::.||.|||:..:.:...::.::.|
Human   497 NQPLPETIEDLENWSLRAKKPKQEP 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	138/520 (27%)
		MFS	161..544	CDD:119392	109/394 (28%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	138/520 (27%)
		MFS	96..493	CDD:119392	110/417 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..542		1/7 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030