DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	532	Identity:	138/532 - (25%)
Similarity:	253/532 - (47%)	Gaps:	34/532 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTI 105
            :|.::|..||:|.|...|:.:|:|..|..:....|||:...|.|..|   :.:::.:...|...:
Human     6 LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP---ADANLSKNGGLEVWL 67

  Fly   106 PK-KNSAWDDCHRYAA--------NISDAI-SGYTDPSGQYCLKEYFTITSETCGRDFKFRDEEK 160
            |: :....:.|.|:.:        |.::|. :|.|:|.....:.:..|..|
Human    68 PRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS-------------- 118

  Fly   161 TISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSS 225
            ||.||:.:.|.......:..::..||..:|..:.||.|||.|||.:|.:....:|:.|...:.:.
Human   119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAP 183

  Fly   226 NYSMFLVFEFLD-MAV-GSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQH 288
            |:.::..|..|. ||: |.:|  ....|.:|.:....|....|:|...|:||:..|..:|..|.|
Human   184 NFPIYCAFRLLSGMALAGISL--NCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH 246

  Fly   289 WRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLN-DLLTS 352
            ||.|..::.||.....::.|...||.||..|.|..:.....|:|.||||.:.....:|: ::|.:
Human   247 WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRA 311

  Fly   353 NRQKLSQANESQYPIMRAVVFFSLRIANCCL--CWFTHTLIALGLSLNSVNLGGNKYTNFMLNGF 415
            :.||.....:.|...|..:...:||....||  .||..:....||.::....|.:.|...::.|.
Human   312 SLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGA 376

  Fly   416 IQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQIL 480
            :.:|..|:..::::.:|||.:..|::||..||:..:..:|.|......:|.::||..:..||..:
Human   377 VDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCI 441

  Fly   481 YFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPE 545
            :.:|.|::||.:|.|.:.:.|.:.|:||:::|...:.|:.|...|..::....:.:..:|:..||
Human   442 FLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPE 506

  Fly   546 TADKVLPTTIEE 557
            |..:.||.|:::
Human   507 TLGQPLPDTVQD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	136/522 (26%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	105/387 (27%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	136/522 (26%)
		MFS	135..505	CDD:119392	100/371 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960