DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and SLC22A16

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens

Alignment Length:	576	Identity:	165/576 - (28%)
Similarity:	266/576 - (46%)	Gaps:	82/576 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGF 103
            :.|...:|.|||:|.:.|.:.....:......::.||...|..|     .|..|.:|.:
Human     7 EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHH-----VCRPPGNVSQ------ 60

  Fly   104 TIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSET--------CGRD-------- 152
            .:...:|.|        ::.|  :|....|||   |:|.|:..:.        |.|:
Human    61 VVFHNHSNW--------SLED--TGALLSSGQ---KDYVTVQLQNGEIWELSRCSRNKRENTSSL 112

  Fly   153 -FKFRDEEK-----------------TISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFAD 199
             :::...:|                 |..|::.:.|:.:|...::..:...|..:|....|||:|
Human   113 GYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSD 177

  Fly   200 RYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAA 264
            |.|||.:|....|...|.|:..:.:.:|..|:...|....|.|......|:..:|.:|.|.|..|
Human   178 RLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242

  Fly   265 ATIITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQ-ILFLWILPESVRWLLSQGAEEKASN 328
            :..:..|:|:|...:......|:.| ||.:::.:...:. ||..|:|||:..||||:|..|:|..
Human   243 SVHLHSFFAVGTLLVALTGYLVRTW-WLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQK 306

  Fly   329 VLRRAARINQRPLPEEQLNDLLT-------SNRQKLSQANESQYPIMRAVVFF----SLRIANCC 382
            ::...|:.|:  ....:|::||:       ||.....|.:...|      :|:    :.|.....
Human   307 IVDIMAKWNR--ASSCKLSELLSLDLQGPVSNSPTEVQKHNLSY------LFYNWSITKRTLTVW 363

  Fly   383 LCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAIC 447
            |.|||.:|.....||||||||||:|.|..|.|.::||......:.||:||||..|..|:...|:.
Human   364 LIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 428

  Fly   448 MGASAAVPADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAP 512
            .|....:|..:|...:...::||.||..:|.::|.:|:|::||.||:..:...|||.|:.|:|||
Human   429 CGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAP 493

  Fly   513 QTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDL---NQAK 565
            .:..|:..:|:.||:...|.||:||.|||..|||..|.|.||.|||..|   |::|
Human   494 FSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	156/553 (28%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	125/394 (32%)
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	156/553 (28%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930