DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and GIT1

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_010022.1	Gene:	GIT1 / 850462	SGDID:	S000000695	Length:	518	Species:	Saccharomyces cerevisiae

Alignment Length:	558	Identity:	110/558 - (19%)
Similarity:	183/558 - (32%)	Gaps:	195/558 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 ITSETCGRDFKFRDEEKTISTEFGIYCEDEWK---------------------LSM--------- 178
            :...|..|..|:..|.:...||..  .:|:||                     :||
Yeast    14 VNENTNPRIIKYDAERRATRTETS--KKDKWKNIVTIIASGFALISDGYVNGSMSMLNKVFVMEY 76

  Fly   179 --------VGTINNVGQFVGIPLGGYF----ADRYGRRTMLAVAGSVSALMGVIRSLSSNYS--- 228
                    |.|..:....|||..|.:|    ||.|.|::.:.||.::..:...:.:.|...:
Yeast    77 GKKNYSSKVSTRVSNAALVGIIFGQFFMGIAADYYSRKSCILVATAILVIGSALCAASHGTTVPG 141

  Fly   229 MFLVFEFLDMAVG---STLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLG------FL-- 282
            ||.:...:...||   ...:||:.|.|.|............|:.:...|..||.|      ||
Yeast   142 MFWMLTVMRGLVGIGVGAEYPTSTLSANESANEYTTTKRGGILVMVTNLPLAFGGPFATIIFLIV 206

  Fly   283 ---ASQVQHWRWLLRVLYAPAVLQILFLWILPESV---RWLLSQGAEEKASNVLRRAARINQRPL 341
               .|..:|...:.|.::|     |...|  |.||   ||       :.|:..:....||.:
Yeast   207 YKICSGTKHLEAIWRTVFA-----IGCFW--PLSVFYFRW-------KTATTEVYEKGRIKR--- 254

  Fly   342 PEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIAL------GLSLNSV 400
                                  ..|...|:.|:..|:...|..||.:..:..      ...::||
Yeast   255 ----------------------NIPYFLALKFYWKRLLGTCGTWFMYDFVTFPNGIFSSTIISSV 297

  Fly   401 NLGGNKYTNF----MLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAG 461
            ....|.....    :|.|.:.:.|:.:...:.||:||:::|..                  .::|
Yeast   298 IKDQNDLVKVAEWNLLLGVLAVLGVPIGAYLSDRIGRKYTLMF------------------GFSG 344

  Fly   462 SLALFLIGKLAITCS----------FQILYFF----------------TSEIFPTNVRNTLLSLC 500
                ::|..|.|.|:          |.|.|.|                :||...|.||.....|.
Yeast   345 ----YIIFGLIIGCAYDQLKKITPLFIIFYAFMNMLGNAGPGDMLGVISSEASATAVRGVFYGLS 405

  Fly   501 SMVGRIGSML-------------APQTPLLAKY---------YIYAPQIL----------FATFA 533
            ::.|:|||::             |..|.::|..         |.:.|..|          |..:.
Yeast   406 AVTGKIGSVVGVECFQPIRDNLGARWTFIIAAICGLIGIIITYFFVPHSLESDLMKQDVEFHNYL 470

  Fly   534 LISGFL-TLAFPETADKVLPTTIE-EARDLNQAKRRSE 569
            :.:|:. .:.|.||.::.:..||| |....|.:|:.:|
Yeast   471 VSNGWTGKMGFDETDEESMVRTIEVEENGTNCSKKNAE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	103/540 (19%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	96/513 (19%)
GIT1	NP_010022.1	MFS_PhT	48..454	CDD:340922	88/466 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000