DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Spns3

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_084208.1	Gene:	Spns3 / 77577	MGIID:	1924827	Length:	514	Species:	Mus musculus

Alignment Length:	529	Identity:	109/529 - (20%)
Similarity:	189/529 - (35%)	Gaps:	131/529 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 CTVPQCDSPSS-------VYEEDWLGFTIPKKNSAWDDCHRYAANISDAISGYTD---------- 131
            |..||...|.|       .|.....|..:|..........|:.|.::.|:..|.:
Mouse     5 CLKPQTGGPQSQSLSQGGQYGALASGTCLPPSTPVPWSLPRWRAYLAAAVLCYINLLNYMNWFII 69

  Fly   132 PSGQYCLKEYFTITSETCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGY 196
            |.....:::||.|:....|          .:.|.| |.|                ..|..|:.||
Mouse    70 PGVLLDVQKYFHISDSHAG----------LLQTVF-ISC----------------LLVSAPVFGY 107

  Fly   197 FADRYGRRTMLAVAGSVSALMGVIRS-LSSNYS--MFLVFEFLDMAVG--STLFPTAFLLAIELV 256
            ..|||.|:.:|:....:.:..|:..| :|..||  .||...|:.....  ||:.||   :..:|.
Mouse   108 LGDRYNRKAILSFGILLWSGAGLSSSFISYQYSWLFFLSRGFVGTGAASYSTIAPT---VLGDLF 169

  Fly   257 GPKRRVAAATIITIFYALGEAFLGF-----LASQVQHWRWLLRVL-YAPAVLQILFLWILPESVR 315
            ...:|..|..:..||..:|.. ||:     :|....:|||.||:: ...|:...|.:.::|:
Mouse   170 VKDQRTCALAVFYIFIPVGSG-LGYVLGSTVAELTGNWRWALRLMPCLDAMALALLILLVPD--- 230

  Fly   316 WLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLSQANESQYPIMR--AVVFFSLRI 378
              :.:||.||...|..||.|                     .|...:.:| :.|  :.||.:|.:
Mouse   231 --VPRGAAEKQGEVAVRAPR---------------------SSWCEDVRY-LGRNWSFVFSTLGV 271

  Fly   379 ANCCLCWFTHTL------------IALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRV 431
            .  .:.:.|..|            :..||.|.......:...: ::.|.:.:...::.:::....
Mouse   272 T--AIAFVTGALGFWAPKFLFEARVVHGLQLPCFQEQCHSQDS-LIFGALTVATGIIGVMLGAEA 333

  Fly   432 GRRHS---------LCASMLLC-AICMGASAAVPADNYAGSLALFLIGKLAITCSFQILYFF--- 483
            .||:.         :|||.|.. |.|:..:..:.:.....|.....:|:|.::|::.::...
Mouse   334 SRRYKKVNPRAEPLICASSLFATAPCLYLALILASRTLLASYVFLALGELLLSCNWAVVADILLS 398

  Fly   484 --------TSEIFPTNVRNTLLSLCS--MVGRIGSMLAPQTP--LLAKYYIYAPQILFATFALIS 536
                    |:|.....|.:.|....|  :.|.|.|:|..:.|  .|..:.......|...||::.
Mouse   399 VVVPRCRGTAEALQITVAHVLGDAGSPYLTGLISSVLQAERPDSYLQHFLSLQHSFLCCAFAIVL 463

  Fly   537 G---FLTLA 542
            |   ||..|
Mouse   464 GGGFFLLTA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	109/529 (21%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	92/435 (21%)
Spns3	NP_084208.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		5/16 (31%)
		MFS	53..470	CDD:119392	97/477 (20%)
		MFS_1	55..418	CDD:284993	83/423 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910