DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and slc22a15.2

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001039179.1	Gene:	slc22a15.2 / 734018	XenbaseID:	XB-GENE-5824718	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	527	Identity:	133/527 - (25%)
Similarity:	227/527 - (43%)	Gaps:	68/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLG 102
            ||...:.||:||          |......||.::..|:.|           |.|...|     |.
Frog     3 LDEAFLYIGEFG----------CCQKRLTAFLTLLQVYVA-----------CQSMLIV-----LV 41

  Fly   103 FTIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEEKTISTEFG 167
            ..:|:          |..:..|..:.          ||.:|       :.....:...:|.:|:.
Frog    42 GAVPE----------YLIDNEDISAS----------KEEYT-------KHLHDTNNFTSIVSEWH 79

  Fly   168 IYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLV 232
            :...:.:|:::..::...|..:|..|.|..:|:.|||.:...........|...:|:.:|.:|.|
Frog    80 LIKNEAYKVNLASSLFFAGLLIGNILFGPLSDKLGRRPVYLSGLFFDITFGYCTALAPSYEVFAV 144

  Fly   233 FEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLY 297
            ..|....:...:...:|:|..|.||........::..:.:|:|.||...|...:::||.|..|..
Frog   145 SRFFVGIMNGGMALVSFVLTQEYVGKSYWALTGSLTNLIFAVGIAFYALLGFYIRNWRTLAFVAN 209

  Fly   298 APAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLL-TSNRQKLSQAN 361
            :|.:...|..::||||.|||.|.|...:|..||:..|..|....|..:|.... ||::...|..:
Frog   210 SPGIFFFLLSFLLPESPRWLYSHGYTTEAEGVLQSMAVGNGVERPVVKLKSCPGTSSKSAHSVFD 274

  Fly   362 ESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLV 426
            ..:|.::|......:.|      |:..:|:..||:||:..|.||.|.|..|.|.:::|...|.|.
Frog   275 LVKYGVLRWRTILLMYI------WYVCSLVYYGLTLNAGELKGNLYLNVALYGLVEVPAFPLCLY 333

  Fly   427 IMDR--VGRRHSLCASMLLCAICMGASAAVPADNYAGSL----ALFLIGKLAITCSFQILYFFTS 485
            .:::  .|||.:....:.........:..:|..|  |.|    .|.|.|||:::.:|.::|.:||
Frog   334 FIEKSWSGRRKATAGFLGFAGFACIFTIFLPETN--GDLLNPTVLALFGKLSVSAAFNVVYIYTS 396

  Fly   486 EIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKV 550
            |::||.|||..|.:|:|..|.|.:|:|..|.:.......|.:.|....:.:|.|:|..|||.:|.
Frog   397 ELYPTVVRNAGLGVCAMACRFGGILSPFIPTMKSLNPSMPFVAFGISGISAGILSLLLPETRNKP 461

  Fly   551 LPTTIEE 557
            :..:||:
Frog   462 IAESIED 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	128/514 (25%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	106/389 (27%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:391944	110/431 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930