DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a16

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_081848.1	Gene:	Slc22a16 / 70840	MGIID:	1918090	Length:	649	Species:	Mus musculus

Alignment Length:	553	Identity:	144/553 - (26%)
Similarity:	244/553 - (44%)	Gaps:	47/553 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EDNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQC------DSP 92
            |..:::.|...||.|||:||:.|::.....|......:|.||.:....|.|..|..      .:.
Mouse     2 ESCNVELIFDHIGHFGRFQIVLYLICAYQSLSCGIHYLSSVFLSIIPEHACKPPGMVRKAVFHNV 66

  Fly    93 SSVYEEDWLGFTIP----------KKNSAWD--DCHR----YAANISDAISGYTDPSGQYCLKEY 141
            |:...||.|....|          :....|:  .|.|    ..:::....|||...|.  |...|
Mouse    67 SAWRLEDILALRSPEHKDHIMVELQDGEIWELTRCSRTWRENTSHLGYEYSGYKHDSP--CFDGY 129

  Fly   142 FTITSETCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTM 206
              :..::..|:...|:        |.:.|:.:|...|:..:...|..:|.....|.:||:|||..
Mouse   130 --VYDQSKWRNSAVRN--------FNLVCDQKWYARMIQPLIIFGVMLGSITFSYLSDRFGRRMA 184

  Fly   207 LAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIF 271
            |..........|:......:|..|::..|..:...|..|...|:..:|::|.|.|..|:..:..|
Mouse   185 LWCTSIGVFFFGIASLFIFDYLSFMITRFFLVMASSGYFVVVFVYVMEIIGKKARTWASIHLNTF 249

  Fly   272 YALGEAFLGFLASQVQHWRWLLRVLYAPAVLQ-ILFLWILPESVRWLLSQGAEEKASNVLRRAAR 335
            :|:| |.|..|||.:....||.:::....... ||..|:|||:..||||:|..::|...:...|.
Mouse   250 FAIG-AMLVALASYLLKTWWLYQIILCIVTTPFILCCWMLPETPFWLLSEGRYKEAQGTVDTMAV 313

  Fly   336 INQRPLPEEQLNDLLTSNRQKLSQANESQYPIMR---AVVFFSLRIANCCLC----WFTHTLIAL 393
            .|:....:  |.:||:.:..:  ..|:|.:.|.:   |.:|.:|.:|...|.    |||..|...
Mouse   314 WNKSSSCD--LVELLSLDVTR--SHNKSPHSIRKHRLADLFHNLDVAKMTLIVWLDWFTANLGYY 374

  Fly   394 GLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADN 458
            ......:....|:....:|.|.::||..:...:.:.|||||.::...:|:.::.......:|:|.
Mouse   375 MFGKEVIRRKENEPLYLLLVGAMEIPAYICLCIWLKRVGRRKTMLLFLLVSSLTCMLHVVMPSDY 439

  Fly   459 YAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIY 523
            ......:.|:.|..|:..|..:|.:|:|::||.||...:...:||..:.|:..|.|...:|.:|:
Mouse   440 KTAKRMVALLVKSVISSVFAFIYLYTAELYPTTVRCLAVGSSNMVSHVSSIFIPFTSHFSKVWIF 504

  Fly   524 APQILFATFALISGFLTLAFPETADKVLPTTIE 556
            .|||||...|::||.|:|..|||.|..:.:|.|
Mouse   505 LPQILFGILAILSGLLSLKLPETQDTPMKSTWE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	139/537 (26%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	105/390 (27%)
Slc22a16	NP_081848.1	2A0119	14..535	CDD:273328	139/537 (26%)
		MFS	163..525	CDD:119392	101/366 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..560		2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930