Protein Alignment CG7458 and SLC22A5

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 160/568 - (28%)
• Similarity: 279/568 - (49%)
• Gaps: 46/568 - (8%)

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGF 103
            |.:...:|::|.:|.:.:.||...::.|.|..:|.||..:|..|||.||...:.||.    |...
Human     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSA----WRNH 65

  Fly   104 TIPKK----NSAWDDCHRY-AANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEE--KT 161
            |:|.:    ......|.|| .|.|::..:...:|.....|.:   :..|:|...::|..:.  .|
Human    66 TVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQ---LEQESCLDGWEFSQDVYLST 127

  Fly   162 ISTE------------------------FGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYG 202
            |.||                        :.:.|||:||..:..::..||..:|..:.|..:||:|
Human   128 IVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFG 192

  Fly   203 RRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGS-TLFPTAFLLAIELVGPKRRVAAAT 266
            |:.:|.|...:......::..|.|:.||:|. |:.:.:|. :.:..||:|..|::|...|:..:|
Human   193 RKNVLFVTMGMQTGFSFLQIFSKNFEMFVVL-FVLVGMGQISNYVAAFVLGTEILGKSVRIIFST 256

  Fly   267 I-ITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVL 330
            : :.||||.|...|...|..::.||.||..|..|.||.:...|.:|||.|||:|||..|:|..::
Human   257 LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 321

  Fly   331 RRAARINQRPLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIAN--CCLCWFTHTLIAL 393
            |:||:.|...:|....:   .|..|.||...:..:.|:..:..:::|:..  ..:.|.|.::...
Human   322 RKAAKANGIVVPSTIFD---PSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYF 383

  Fly   394 GLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADN 458
            ||||::.||.|:.:.|..|:..:::|..:|..:::..:.||:|:..::.|....:.....||.|.
Human   384 GLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDL 448

  Fly   459 YAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIY 523
            |..:..|.::||..:|.:|.::|.:|:|::||.|||..:.:.|...|:||:|:|....|..|..:
Human   449 YYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRF 513

  Fly   524 APQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571
            .|.||..:..:::..|||..||:....||.||::...:...|.|...|
Human   514 LPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPS 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	154/542 (28%)
		MFS	161..544	CDD:119392	119/410 (29%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	154/542 (28%)
		MFS	162..534	CDD:119392	113/375 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.980