Protein Alignment CG7458 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 154/518 - (29%)
• Similarity: 244/518 - (47%)
• Gaps: 46/518 - (8%)

  Fly    37 SLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFS---ISYVFTASTVVHRCTVP-------QCD- 90
            ::|.||.::|:.|.:|...:::||   |.:|.|:   :..||...|..|.|..|       :|.
Human     3 TVDDILEQVGESGWFQKQAFLILC---LLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGW 64

  Fly    91 SPSSVYEEDWLGFTIPKKNSAWD----DCHRYAANISDAISGYTDPSGQYCLKEYFTITSE---- 147
            ||:   ||  |.:|:|....|.:    .|.||..:.:.:.....||     |....|..|.
Human    65 SPA---EE--LNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDP-----LASLATNRSHLPLG 119

  Fly   148 TCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLG-GYFADRYGRRTMLAVAG 211
            .|...:.:.....:|.|||.:.|.|.|||.:..:..|.|...| .|| ||||||:||:..|....
Human   120 PCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFG-SLGVGYFADRFGRKLCLLGTV 183

  Fly   212 SVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGE 276
            .|:|:.||:.:.|.||...|:|..|...|....:...:.|..|.||...|...|.:..:.:.:|.
Human   184 LVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGL 248

  Fly   277 AFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPL 341
            ..|..||..:.|||||...:..|..|.:|:.|.:|||.||||||....:|..::...|:.|.: |
Human   249 VALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK-L 312

  Fly   342 PEEQLNDLLTSN--RQKLSQ--ANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNL 402
            |...|..|....  .:|||.  |:..:.|.:|...|..:.:      |||.:::..||.|:....
Human   313 PPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYL------WFTDSVLYQGLILHMGAT 371

  Fly   403 GGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFL 467
            .||.|.:|:.:..::|||..:.|:.:|||||.:.:..|.||..........:..|.:..::.:..
Human   372 SGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMC 436

  Fly   468 IGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPL-LAKYYIYAPQILF 529
            :|::.||.:.|::....:|::||.|||..:.:||.:..||.::.|.... |.:.:...|.|||
Human   437 VGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILF 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	151/509 (30%)
		MFS	161..544	CDD:119392	119/375 (32%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	149/507 (29%)
		MFS	118..484	CDD:119392	115/373 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960