DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_072146.1	Gene:	Slc22a23 / 64559	RGDID:	620302	Length:	689	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	140/579 - (24%)
Similarity:	230/579 - (39%)	Gaps:	80/579 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DEDNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAF--FSISYV----------------FTAST 79
            |.|.|:...|..:|  |.||....||..:|.||..|  ||.|::                ...:|
  Rat    79 DYDGSVLPFLGGLG--GGYQKTLVVLTWIPALFIGFSQFSDSFLLDQPNFWCHGAGKGTELAGAT 141

  Fly    80 VVHRC-TVPQCDSPSSVYEEDWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFT 143
            |..|. .:....|||:.          |...::|..... .:|.||. .....|.|    |....
  Rat   142 VTGRWGDMGNWTSPSAT----------PFSTASWGTTSN-RSNSSDT-PPLPSPPG----KGNND 190

  Fly   144 ITSETCGRDFKFRDE-EKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTML 207
            ...|....|:..|.. .:.:.:::.:.|::.||:.:......||...|..:.|..||..|||.:|
  Rat   191 SNCECHAWDYGIRTGLVQNVVSKWDLVCDNAWKVHVAKFSLLVGLIFGYLITGCIADWVGRRPVL 255

  Fly   208 AVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFY 272
            ..:.....:.|:..:||.|.:||....|.:....:.:..|.:.|.|||..|.:|. ..|::..|.
  Rat   256 LFSVIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRF-IITMVASFV 319

  Fly   273 AL-GEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARI 336
            |: |:..:..||:..:.|:.|..::..|.:|.:|:..|.|||:|||::....|.|..::....:.
  Rat   320 AMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLILYLTQK 384

  Fly   337 NQRPLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSL--RIANCCLCWFT----HTLIALGL 395
            | ...||..:..::....::||: ...:..|::.|...:|  .|...|:...|    |...|..:
  Rat   385 N-CVSPESDIKGVMPELEKELSR-RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSM 447

  Fly   396 SLNSVN--LGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCA------------- 445
            ..:.|.  |..|.|.::.....|.:...|...:::..:|||..|...|:|.|
  Rat   448 MGHEVKVPLLENFYADYYTMASIALASCLAMCLVVRFLGRRGGLLLFMILTALASLLQLGLLNLI 512

  Fly   446 --------------ICMGASAAVPADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTL 496
                          :.:|.|.:| .|.:  |:|..::|..|......:..||.:||.||.:|...
  Rat   513 GKYSQHPDSELQLKLAVGMSDSV-KDKF--SIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGG 574

  Fly   497 LSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTI 555
            |.|.......|.:.||...|..:...:...|:||...||.....|..||:.|:.||..|
  Rat   575 LGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENI 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	135/563 (24%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	100/418 (24%)
Slc22a23	NP_072146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		7/31 (23%)
		MFS_SLC22A23	187..608	CDD:341002	98/426 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100