DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_071606.1	Gene:	Slc22a4 / 64037	RGDID:	621149	Length:	553	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	154/540 - (28%)
Similarity:	262/540 - (48%)	Gaps:	42/540 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGF 103
            |.::..:|.:|.:|.:.:.||...::.|.|..:|.||.|.|..|||.||...:.||.    |...
  Rat     5 DEVIAFLGDWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPHTVNLSSA----WRNH 65

  Fly   104 TIPKK----NSAWDDCHRY-AANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEE--KT 161
            :||.:    ......|.|| .|.|::..:...:|.....|::   :..|:|...:::..:.  .|
  Rat    66 SIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGLDVDLEQ---LEQESCLDGWEYSKDVFLST 127

  Fly   162 ISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSN 226
            |.||:.:.|||:||..:..::..||...|..:.|..:||:||:.:|....:|......::..|:|
  Rat   128 IVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTN 192

  Fly   227 YSMFLVFEFLDMAVGS-TLFPTAFLLAIELVGPKRRVAAATI-ITIFYALGEAFLGFLASQVQHW 289
            :.||.|. |..:.:|. :.:..||:|..|::....|:..:|: :..|:|:|...|...|..::.|
  Rat   193 WEMFTVL-FAIVGMGQISNYVVAFILGTEILSKSVRILFSTLGVCTFFAIGYMVLPLFAYFIRDW 256

  Fly   290 RWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQ--------RPLPEEQL 346
            |.||..|..|.:..:...|.:|||.|||:||...|:|..::::||::|.        .||..::|
  Rat   257 RMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFEEAEQIIQKAAKMNGIMAPAVIFDPLELQEL 321

  Fly   347 NDLLTSNRQKLSQANESQYPIMRAVVFFSLRIAN----CCLCWFTHTLIALGLSLNSVNLGGNKY 407
            |.|             .|..:....:|.:..||.    ..:.|...::....||||..||.|:.|
  Rat   322 NSL-------------KQQKVFILDLFKTRNIATITVMSVMLWMLTSVGYFALSLNVPNLHGDVY 373

  Fly   408 TNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLA 472
            .|..|:|.|::|......:::..:.||:.:...:......:.....||.|....|:.|.::||..
  Rat   374 LNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLVQVVPEDYNFVSIGLVMLGKFG 438

  Fly   473 ITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISG 537
            :|.:|.:||.||:|::||.|||..:.:.||..|:||::||....|..|....|.||..:..::.|
  Rat   439 VTSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIG 503

  Fly   538 FLTLAFPETADKVLPTTIEE 557
            .:||.|||:....||..:|:
  Rat   504 IITLFFPESFGVTLPENLEQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	152/528 (29%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	116/396 (29%)
Slc22a4	NP_071606.1	2A0119	12..519	CDD:273328	151/527 (29%)
Slc22a4	NP_071606.1	MFS	123..510	CDD:119392	116/400 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020