Protein Alignment CG7458 and SLC22A23

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_011513103.1
• Gene: SLC22A23 / 63027
• HGNCID: 21106
• Length: 710
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 143/597 - (23%)
• Similarity: 232/597 - (38%)
• Gaps: 95/597 - (15%)

  Fly    33 DEDNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAF--FSISYVFTASTVVHRCTVPQCDSPSSV 95
            |.|.|:...|..:|  |.||....:|..:|.||..|  ||.|::......       .|......
Human    79 DYDGSVLPFLGGLG--GGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNF-------WCRGAGKG 134

  Fly    96 YE-------------EDWLGF-TIPKKNSAWDDCHRYAANISDAISGYTDP-------------- 132
            .|             .:|... |.|...:.|:.... .:|.|.|..|.|.|
Human   135 TELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGN-RSNSSGADGGDTPPLPSPPDKGDNASNC 198

  Fly   133 ---SGQYCLKEYF--TITSETCGR----------DFK-FRDEEKTISTEFGIYCEDEWKLSMVGT 181
               :..|.::...  .:.|:.|.:          |.| :|.|     ..:.:.|::.||:.:...
Human   199 DCRAWDYGIRAGLVQNVVSKCCQQQETGALPWDTDTKRWRPE-----LNWDLVCDNAWKVHIAKF 258

  Fly   182 INNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFP 246
            ...||...|..:.|..||..|||.:|..:.....:.|:..:||.|.:||....|.:....:.:..
Human   259 SLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIIL 323

  Fly   247 TAFLLAIELVGPKRRVAAATIITIFYAL-GEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWIL 310
            |.:.|.|||..|.:|. ..|::..|.|: |:..:..||:..:.|:.|..::..|.:|.:|:..|.
Human   324 TLYALRIELCPPGKRF-MITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIF 387

  Fly   311 PESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFS 375
            |||:|||::....|.|..::....:.| |..||..:..::....::||: ...:..|::.|...:
Human   388 PESLRWLMATQQFESAKRLILHFTQKN-RMNPEGDIKGVIPELEKELSR-RPKKVCIVKVVGTRN 450

  Fly   376 L--RIANCCLCWFT----HTLIALGLSLNSVN--LGGNKYTNFMLNGFIQIPGLLLPLVIMDRVG 432
            |  .|...|:...|    |...|..:..:.|.  |..|.|.::.....|.:...|...|::..:|
Human   451 LWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLG 515

  Fly   433 RRHSLCASMLLCAIC-------------------MGASAAVPADNYAGSLALFLIGKLAITCSFQ 478
            ||..|...|:|.|:.                   .|.|.:| .|.:  |:|..::|..|......
Human   516 RRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSV-KDKF--SIAFSIVGMFASHAVGS 577

  Fly   479 ILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAF 543
            :..||.:||.||.:|...|.|.......|.:.||...|..:...:...|:||...||.....|..
Human   578 LSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLL 642

  Fly   544 PETADKVLPTTI 555
            ||:.|:.||..|
Human   643 PESRDQNLPENI 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	138/581 (24%)
		MFS	161..544	CDD:119392	102/410 (25%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	106/414 (26%)
		MFS	259..>388	CDD:119392	36/129 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010