DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	548	Identity:	162/548 - (29%)
Similarity:	277/548 - (50%)	Gaps:	27/548 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGF 103
            |.:...:|::|.:|.:.:.||...::.|.|..:|.||..:...|||.:|...:.||.    |...
Mouse     5 DEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIPDTVNLSSA----WRNH 65

  Fly   104 TIPKKNSAWDD----CHRY----AANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEE- 159
            :||.:.....:    |.||    .||.|:.   ..:|.....|::   :..|.|...::: |::
Mouse    66 SIPMETKDGPEVPQKCRRYRLATIANFSEL---GLEPGRDVDLEQ---LEQENCLDGWEY-DKDI 123

  Fly   160 --KTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRS 222
              .||.||:.:.|:|:||..:..:...||..:|..:.|..:||:||:.:|.:..::......|:.
Mouse   124 FLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMHTGFSFIQV 188

  Fly   223 LSSNYSMF-LVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATI-ITIFYALGEAFLGFLASQ 285
            .|.|:.|| |::..:.|...|. :..||:|..|::....|:..||: :.||:|.|...|...|..
Mouse   189 FSVNFEMFTLLYTLVGMGHISN-YVAAFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVLPLFAYF 252

  Fly   286 VQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLL 350
            ::.||.||..:..|.||.....|.:|||.|||:|||..::|..::|:||:||....|....:...
Mouse   253 IREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSE 317

  Fly   351 TSNRQKLSQANESQYPIMRAVVFFSLRIAN--CCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLN 413
            |:..|..|......:.|...|...::||..  ..:.|.|.::...||||::.||.||.|.|..|.
Mouse   318 TNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLL 382

  Fly   414 GFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQ 478
            ..:::|..:|..:::..|.||:|:..|:.|....:.....||:|.:..|..|.::||..||.::.
Mouse   383 AAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYS 447

  Fly   479 ILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAF 543
            ::|.:|:|::||.|||..:.:.|...|:||:|:|....|..|....|.||..:..:::..:||.|
Mouse   448 MVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFF 512

  Fly   544 PETADKVLPTTIEEARDLNQAKRRSERS 571
            ||::...||.||:|.:.:.:.|:|...|
Mouse   513 PESSGVSLPETIDEMQKVKKLKQRQSLS 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	155/522 (30%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	120/386 (31%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	155/522 (30%)
		MFS	123..513	CDD:119392	120/390 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.990