DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and slc22a16

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	567	Identity:	160/567 - (28%)
Similarity:	259/567 - (45%)	Gaps:	71/567 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLG 102
            ::.:...:|.|.|:|...|.......:......::.||...|....|. |..:....:|:.  |.
Zfish     5 VERLFDELGHFKRFQACLYFAAIFQAISCGIHYLASVFLVETPKFLCN-PPLNITDVLYKN--LS 66

  Fly   103 FTIPKKNSAWDDCHRYAANISDAISGY----------TDPSGQY----CLK-----------EYF 142
            ||                :::|..:.|          |....|:    |||           |:|
Zfish    67 FT----------------SLADIWTHYKTGDGPVVVRTSQGDQWELSPCLKALRLDAINFQYEFF 115

  Fly   143 TITS-ETCGR-DFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRT 205
            ...| |:||. .:...:.|::|.|::.:.||.||...:......:|..:|..:.|..|||.|||.
Zfish   116 GNKSVESCGAFVYDHSEVEQSIVTDWDLVCEREWLAKLTQPTFMLGVLIGALMFGDAADRIGRRP 180

  Fly   206 MLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITI 270
            :|........:.||..:.:.||.:|:|..||...|.|......|:...|..|.|.|...:..:..
Zfish   181 VLMATSLCQFIFGVTVAFTGNYYLFVVMRFLLATVSSGYLVVVFVYVTEFTGIKVRTWTSMHVHA 245

  Fly   271 FYALG---EAFLGFLASQVQHWRWLLRVLYAPAVLQ-ILFLWILPESVRWLLSQGAEEKASNVLR 331
            .:|:|   .|.:|:|   |:.| |:.:::...:... :|:.|..||:..:|:::|..::|..:|.
Zfish   246 AFAVGIMVVALVGYL---VRVW-WIYQIILTLSTSPFLLYCWKFPETPFYLMAKGRYKEAQELLD 306

  Fly   332 RAARINQRPLPEEQLNDL--------LTSNRQKLSQANESQYPIMRAVVFFSL----RIANCCLC 384
            ..|.||..| |..:::||        |..|:    ||.|.:..:....:|.||    |.|.|...
Zfish   307 TMAYINGLP-PTLKVSDLQDGCDRTPLKDNK----QAMEVEKRLSMLDMFGSLKMAGRSATCWAI 366

  Fly   385 WFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMG 449
            ||..:|.....||.|||||||:|.|..|.|.:::|..|:....|||.||:.:...::||..:...
Zfish   367 WFIGSLGYYVFSLGSVNLGGNQYINLFLAGAVEVPSYLIGCFAMDRFGRKKTCAPALLLGGVACM 431

  Fly   450 ASAAVPADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQT 514
            ....||.|....::.|.:.||.||..:|.::|.:|.|::||.:|:..:...||:.|:||::||..
Zfish   432 LIIVVPQDVEVLAIVLSMTGKFAIAIAFGLIYLYTCELYPTIIRSLAVGSGSMMCRVGSVVAPFC 496

  Fly   515 PLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDL 561
            ..||..:||.||::....|.|.|.||:..|||..:.|.:|:|||..|
Zfish   497 VYLADIWIYLPQLIVGILAFIIGILTMFLPETLGEPLTSTLEEAEAL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	155/550 (28%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	123/398 (31%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	155/550 (28%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	117/376 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930