DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	540	Identity:	148/540 - (27%)
Similarity:	234/540 - (43%)	Gaps:	81/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IGQFGRYQIINYVLLCVPM-LFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTIPKK 108
            :|:.|.||:....||.|.: |:.|..:|......:|            ||  |..| |...:|.:
Human    10 VGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGAT------------PS--YHWD-LAELLPNQ 59

  Fly   109 NSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEEKTISTEFGIYCEDE 173
            :.            .:..:|.....|.:.|    |.......:...|.....:|::|:.:.....
Human    60 SH------------GNQSAGEDQAFGDWLL----TANGSEIHKHVHFSSSFTSIASEWFLIANRS 108

  Fly   174 WKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDM 238
            :|:|...:....|.|||:...|..:||:||:.:.....::..|..:....|.:|..|.|..||..
Human   109 YKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVG 173

  Fly   239 AVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQ 303
            .:...:...||:|..|.||......|.:|..:|:|:|.|....|...::.||.|..::.....:.
Human   174 MMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVV 238

  Fly   304 ILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLSQANES----- 363
            .|....:|||.|||.|||...:|...|...|:.|::          |.........||.|
Human   239 FLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK----------LKCTFSLTHPANRSCRETG 293

  Fly   364 ------QYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLL 422
                  :|.::.......:.|      ||..:|:..||:|::.:|||:.|.|..|:|.|:||...
Human   294 SFLDLFRYRVLLGHTLILMFI------WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYP 352

  Fly   423 LPLVIMDR--VGRRHS----LCASMLLCAICM--------GASAAVPADNYAGSLALFLIGKLAI 473
            |.:.::::  .||:.:    ||...|.|.|.|        |..|.|      .|.:|.|:|||.|
Human   353 LCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVV------NSHSLSLLGKLTI 411

  Fly   474 TCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYA-PQILFATFALISG 537
            :.:|.|:|.:|||::||.:||..|..|||..|:|.::||..|.| ||..:: |.|:|....|.||
Human   412 SAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSL-KYVQWSLPFIVFGATGLTSG 475

  Fly   538 FLTLAFPETADKVLPTTIEE 557
            .|:|..|||.:..|..|..:
Human   476 LLSLLLPETLNSPLLETFSD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	147/534 (28%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	121/408 (30%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	113/380 (30%)
		MFS_1	111..450	CDD:284993	104/360 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930