Protein Alignment CG7458 and SLC22A17

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_065105.3
• Gene: SLC22A17 / 51310
• HGNCID: 23095
• Length: 649
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 156/657 - (23%)
• Similarity: 251/657 - (38%)
• Gaps: 163/657 - (24%)

  Fly     2 TSQKEGNGYRRSDSKTTGHADAEAATQTAGGD------------EDNSLDAILVRIGQFGRYQII 54
            |.|.:|...|..:    |..|       ||||            ...|.:|:|.::|..|..|.:
Human    43 TEQLQGERERERE----GEGD-------AGGDGLGSSLSLAVPPGPLSFEALLAQVGALGGGQQL 96

  Fly    55 NYVLLCVPMLFNAF-FSISYVFTASTVVHRCTVPQCDSPSSVYEE--DWLGFTIPKKNSAWDDCH 116
            ...|.|:|:||.|. .:...:||.:..:| |........:|.:|:  :..|.::.....|.....
Human    97 QLGLCCLPVLFVALGMASDPIFTLAPPLH-CHYGAFPPNASGWEQPPNASGVSVASAALAASAAS 160

  Fly   117 RYAANISDAISGYTDPSGQYCLKEYF-----TITSETCGRDFKFRDEEKTISTEFGIYCEDEWKL 176
            |.|.:...:.||:..|...:|||::.     .:|:...|              ::.:.|:..|::
Human   161 RVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIG--------------QWDLVCDLGWQV 211

  Fly   177 SMVGTINNVGQFVGIPLGGYFADRYGRRTML--------------AVAGSVSALMGVIRSLSSNY 227
            .:...:..:|...|....||.|||:|||.::              |.|||.:.:|.:      .:
Human   212 ILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMAL------RF 270

  Fly   228 SMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGE-AFLGFLASQVQHWRW 291
            .:..:...:|:.|        :|:.:||..|.:|:..|....:....|. .||| ||...:.||:
Human   271 LLGFLLAGVDLGV--------YLMRLELCDPTQRLRVALAGELVGVGGHFLFLG-LALVSKDWRF 326

  Fly   292 LLRVLYAPAVLQILFLW--ILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNR 354
            |.|::.||.:|.:.:.|  :..||.|||:.:...|:|.:|||..|..|:   |..|   :|....
Human   327 LQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNR---PHGQ---MLGEEA 385

  Fly   355 QKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNL-------------GGNK 406
            |:..|..|:..|:.....|....:.|....|  ..|:.||.:    |.             ||..
Human   386 QEALQDLENTCPLPATSSFSFASLLNYRNIW--KNLLILGFT----NFIAHAIRHCYQPVGGGGS 444

  Fly   407 YTNFMLNGFIQIPGLLLPLVIM----DRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFL 467
            .::|.|...:......|..|.:    ||.|||..|..||.|                .|..:|.|
Human   445 PSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTL----------------TGIASLVL 493

  Fly   468 IG------------------------KLAITCSFQILYFFTS------------EIFPTNVRNTL 496
            :|                        :.||| :|.:|..|:|            |:.||.||...
Human   494 LGLWDCEHPIFPTVWAQQGNPNRDLNEAAIT-TFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRG 557

  Fly   497 LSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDL 561
            |.|...:|.:|.:..|...|...:..:...::.|..||:.....:..|||..|:||   |..||.
Human   558 LGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLP---EVLRDG 619

  Fly   562 NQAKRRS 568
            ...:|.|
Human   620 ELCRRPS 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	138/585 (24%)
		MFS	161..544	CDD:119392	105/452 (23%)
SLC22A17	NP_065105.3	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7136
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960