DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and slc22a15.1

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_031751719.1	Gene:	slc22a15.1 / 448510	XenbaseID:	XB-GENE-959503	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	133/539 - (24%)
Similarity:	241/539 - (44%)	Gaps:	72/539 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LDAILVRIGQFGRYQI-INYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWL 101
            ::..|..:|:.|.||| ::::|..:..|::|..:|......:|..:.                |:
Frog    29 VEGALKLVGEMGIYQIYLSFLLAVLLQLYSATEAIIITILGATPPYH----------------WM 77

  Fly   102 GFTIPKKNSAWDDCHRYAANI-SDAISGYTDPSGQY--CLKEYFTITSETCGRDFKFRDEEKTIS 163
            ..::....|..   .:|.:.: ::...|:....|.:  .:.|:|.:....
Frog    78 NDSLTANGSRG---KQYGSQLPAEGEHGHVVFDGNFTSIVSEWFLVGGAA--------------- 124

  Fly   164 TEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYS 228
                      :::|:..::...|..:|:...|..:||:||:.:.....::..:..|:.:|:..:.
Frog   125 ----------YEVSVSSSVYFGGVLIGVISFGQLSDRFGRKPVYVTGLALEVVFAVMNALTPIFP 179

  Fly   229 MFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLL 293
            :||:..||...:...:...||:|..|.:|.....||.::.::.:|:|.|....:...::.||.|.
Frog   180 LFLLTRFLVGVMNGGMSLVAFVLLNECIGASYWAAAGSLGSLCFAVGIAQFALIGYFIRSWRLLA 244

  Fly   294 RVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLS 358
            .::.......:.....:|||.|||.:||...:|...|....|.|:|     ::.......||| .
Frog   245 LLVNVQGAAVLALSLCIPESPRWLHAQGRLREAQESLLSLGRRNRR-----KVTSFTLCPRQK-D 303

  Fly   359 QANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPG--L 421
            .|:.:....:.:......|.......||..:|:..||:|:|.:|||:.|.|..|:|..::|.  |
Frog   304 SAHSANILTIYSNAILRQRTLIMMWVWFVCSLVYYGLTLSSGDLGGDIYLNLALSGLAELPAYPL 368

  Fly   422 LLPLVIMDRVGRRHSLCASMLLCAICMGASAA-----VPADNYAGSLA------LFLIGKLAITC 475
            .:.|:...|||||.||..     .:|:|..|.     ||....:|.|:      |.|:|||.|:.
Frog   369 CMYLINHKRVGRRGSLAG-----FLCVGGGACLLIMLVPGKTGSGPLSVLNSQTLSLLGKLNISA 428

  Fly   476 SFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLT 540
            :|.|:|.::||::||.|||..:.:|||..|||.::||..|.|...:...|.|:|....:.:|.|:
Frog   429 AFNIVYIYSSELYPTCVRNLGMGVCSMFSRIGGIIAPFIPALRFAHWALPFIVFGAAGVSAGLLS 493

  Fly   541 LAFPETADKVLPTTIEEAR 559
            |..|||....||.|:.:.|
Frog   494 LLLPETLSAPLPETLADLR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	130/524 (25%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	108/395 (27%)
slc22a15.1	XP_031751719.1	MFS	90..497	CDD:421695	113/442 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930