DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and CG7333

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	126/549 - (22%)
Similarity:	238/549 - (43%)	Gaps:	57/549 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTI 105
            :|.:.|.:||:|::..:|.....:..:....|......|..|.|           :..|..|.::
  Fly     6 VLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWC-----------FHADLNGLSV 59

  Fly   106 PKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEE--KTISTEFGI 168
            ....|.:::   .:|:....:.|..:.:|       ...|:..| |::.|..|.  ::|:||...
  Fly    60 EGIRSVYEN---ISASSCTPLLGVVNGTG-------VVSTNRKC-RNWIFNRESGYESITTELKW 113

  Fly   169 YCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVF 233
            .|:.....::..:...:|..||..:.||.:|:.||...|.:|....|....|.|.......|...
  Fly   114 VCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFS 178

  Fly   234 EFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATII-TIFYALGEAFLGFLASQVQHWRWLLRVLY 297
            .|:......|::...::|..|.:.||.|.....|| .:||..|.....:.|..:.:||..|.:..
  Fly   179 RFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLAS 243

  Fly   298 APAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLSQ--- 359
            .||:..:::.:::.||.:|||::...:.|...|::.|:.|:|.:.|...::.:...|::..|
  Fly   244 LPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKYYRERELQDYK 308

  Fly   360 --ANESQYPIMRAVVFFSLRIANCCLCWFTHTL----IALGLSLNSVN-----LGGNKYTNFMLN 413
              ::|..:..|    |.:.|:..     ||.||    :.:.||.:.:|     ||.:.:..|...
  Fly   309 LNSHEDTFLAM----FLTPRLRR-----FTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFT 364

  Fly   414 GFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAV-----PADNYAGSLALFL-IGKLA 472
            ..:.:|..:..|::.:::||:...|.::.:..:...|:..:     |.:| |..||:.: :|:..
  Fly   365 SIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTEN-ALLLAIMVGLGRFG 428

  Fly   473 ITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISG 537
            .|.|:.....:.:||.||:||...:|...::|...|.||.....||:||...|.|..:.......
  Fly   429 ATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFISCLMFFGA 493

  Fly   538 FLTLAFPETADKVLPTTIEEARD--LNQA 564
            .|.|..|||.:|.||.|:.:...  ||::
  Fly   494 GLCLTLPETLNKKLPETLADGEKFALNES 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	122/530 (23%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	96/403 (24%)
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	122/530 (23%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	92/382 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458493
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940