DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and CG14857

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	146/558 - (26%)
Similarity:	236/558 - (42%)	Gaps:	88/558 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYV-FTASTVVHRCTVPQCDSPSSVYEEDWLG 102
            |.||.:.|..||||.:..:||            .|: ||  |.||            .|.::.:|
  Fly     4 DQILEKCGSAGRYQYLMILLL------------GYIAFT--TTVH------------YYSQNIIG 42

  Fly   103 FTIPKKNSAWDDC-HRYAANIS-DAISGYTDPSGQ--YCLK------EYFTITSETCGR-----D 152
            | :|:.   |  | |....|.| :.|:....|.|:  .|.:      :..|:::|||.|     |
  Fly    43 F-VPQH---W--CYHEALENRSFEEIAAIYAPFGKEASCTRLDKIEGDRVTVSNETCQRWIYNYD 101

  Fly   153 FKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALM 217
            |.||    :::.|....|.|.:|..:..::..:|..:|....|...||.||...:.:|.....:.
  Fly   102 FGFR----SMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVG 162

  Fly   218 GVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPK-RRVAAATIITIFYALGEAFLGF 281
            ..:.:.:||...|.:|..:.....:..:...|:|.:|.:.|| |.:|.:..:.|.:.||.....:
  Fly   163 DFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPW 227

  Fly   282 LASQVQHWRWLLRVLYAPAVLQI---LFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPE 343
            |:....:||..|.   ..|:||:   ||.:::.||.:||:::...|.|...|:..|..|..   |
  Fly   228 LSVLAGNWRIYLT---CSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGM---E 286

  Fly   344 EQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIAN----CCLCWFTHTLIALGLSLNSVNLGG 404
            .:..|.....|..:.:...|..|...|.:|..||..|    ..|..||..|.:|..:..|.|:.|
  Fly   287 VKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEG 351

  Fly   405 NKYTNFML----------NGFIQIPGLLLPLVIMDRVGRRHS-----LCASMLLCAICMGASAAV 454
            ...:.|::          :||||  |||     ..||||:.:     ||..:|.||:.:..|...
  Fly   352 MGLSPFVVFSLFAVVVPPSGFIQ--GLL-----QSRVGRKATAFLAMLCTGLLSCALGVALSTEG 409

  Fly   455 PADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAK 519
            ...|....||..|..:|.|:..:.:...|.||:.||.||:..::...:.....|.::|....|..
  Fly   410 AQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGT 474

  Fly   520 YYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEE 557
            ....||.::.|...|.:...||..|||.::.||.|:.:
  Fly   475 KLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLAD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	142/546 (26%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	102/405 (25%)
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	142/546 (26%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	91/356 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.990