DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and CG14856

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	128/564 - (22%)
Similarity:	218/564 - (38%)	Gaps:	79/564 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVV-----HRCTVPQCDSPSSVYEE 98
            |.|||:.|...|||   |:||.:..|.  .|.:|..:.|..|:     |.|...|.::.|  |.|
  Fly     6 DEILVKCGDSHRYQ---YMLLALYGLL--MFIVSRHYFAQNVIGFVPDHWCYHEQLENRS--YAE 63

  Fly    99 DWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGR-----DFKFRDE 158
            ....:...|:.|    |.|.|:...|..:.              |.:||.|.|     |..|
  Fly    64 IAAIYAPFKRPS----CTRLASINMDGSNA--------------TASSEPCNRWIYHYDHGF--- 107

  Fly   159 EKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSL 223
             .:::.:....|:|.:|..:..::..||...|..|.|...||.||...:.:|.....|.......
  Fly   108 -ISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIF 171

  Fly   224 SSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGP-KRRVAAATIITIFYALGEAFLGFLASQVQ 287
            :.....|....|:............|:|.:|.|.| .|.|.....:.:||.||.....:....:.
  Fly   172 AETLLTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLG 236

  Fly   288 HWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTS 352
            .||..:.....|.:|...|.:::.||.:||:::...:.|...|||.|:.|:|.:.|.........
  Fly   237 SWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQH 301

  Fly   353 NRQKLSQANES-------------QYPIMR-AVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLG 403
            .:.|.|:|...             :.|.:| .:::.::..:...||:.|.:....|||:
  Fly   302 CKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSI------ 360

  Fly   404 GNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASM-----------LLCAICMGASAAVPAD 457
             :.:..|.|......|..:....:....||:.:...||           :|.|.....||.|
  Fly   361 -SPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATV--- 421

  Fly   458 NYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYI 522
                .:.|.|:.:..|:.:.......::|:.||.||::.|::..:.....|.::|....|..|:.
  Fly   422 ----MVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFR 482

  Fly   523 YAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKR 566
            .|..|:.....|:|.::.|...||.:|.||.|:.|..:..:.:|
  Fly   483 AASSIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFGKGER 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	121/543 (22%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	85/408 (21%)
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	121/543 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	82/387 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940