DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and CG14855

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	134/563 - (23%)
Similarity:	228/563 - (40%)	Gaps:	82/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQII-----NYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEE 98
            :.||.:.|...|||.:     .|:::.|.|.:.:...||:|     ..|.|...|.:
  Fly     4 EEILAKCGNSSRYQFVLLALYGYLMVVVSMHYFSQNVISFV-----PDHWCYHEQLE-------- 55

  Fly    99 DWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLK--------EYFTITSETCGR---- 151
                             :|..|.|....|.:..||   |.:        :..|::.|.|.|
  Fly    56 -----------------NRSFAEIEKIYSQFEKPS---CTRLEKIDEDGQNHTLSRERCNRWIYK 100

  Fly   152 -DFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSA 215
             ||.:    |:::||....|::.:|..:..::..||...|....|...||.||...|.:|.....
  Fly   101 YDFGY----KSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGRIRALILANWCGF 161

  Fly   216 LMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPK-RRVAAATIITIFYALGEAFL 279
            |.......:.:.:.|.:..|:............::|.:|.|.|. |.|...|::..||.||....
  Fly   162 LGDFSTIFAGSLTSFSISRFISGLAADANSYLMYILILEYVSPSLRNVGLNTVLGSFYCLGLIGA 226

  Fly   280 GFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEE 344
            .:||..|.|||..|.....|.:|..||.:::.||.:||:::...:.|...|.|.|:||:|.:.::
  Fly   227 CWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADK 291

  Fly   345 QLNDL-LTSNRQKLSQANESQY---------PIMRAVVFFSLRIANCCL-CWFTHTLIALGLSLN 398
            ...|. :...:......|:.::         |.||:..|..|.|....: |:.|       ::.|
  Fly   292 DFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNT-------IARN 349

  Fly   399 SVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSL 463
            ...||.:.:..|.||.....|...|..::.||:||:.:....|.:..| ...:|.:.....:...
  Fly   350 VEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGI-FAVAAGLVISQGSNRN 413

  Fly   464 ALFLIGKLAITCSFQILYF------FTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYI 522
            .|.|:| |.:...|.:...      |::|:.||:||...:::..:.|...|.|:|....|..||.
  Fly   414 VLLLVG-LTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYK 477

  Fly   523 YAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAK 565
            .||.|:.....|...::.|..|||.:|.||.::.|..:..:.:
  Fly   478 PAPSIILGLLFLSGAYVCLLLPETRNKKLPMSLAEGEEFGRGE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	131/543 (24%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	98/400 (25%)
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	129/541 (24%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	94/380 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458487
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990