DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and slc22a2

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	558	Identity:	154/558 - (27%)
Similarity:	261/558 - (46%)	Gaps:	41/558 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYE---- 97
            :.:.||...|.|||.||..:...|:..:..:|..:..||...|..|.|..|   ..|.:.|
Zfish     3 TFEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDP---GVSEIRERCGW 64

  Fly    98 --EDWLGFTIPKKN----SAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETC--GRDFK 154
              :|....|:|..|    :::..|.|:..:.:.......:|.|.:...:...:...:|  |.::.
Zfish    65 SLQDARRATVPLINGSSGASYSQCGRFDVDWNATGLSCENPDGDFNQSQLSVMPMMSCVDGWEYD 129

  Fly   155 FRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGV 219
            :...:..: |||.:.|.|.|.:.|.....::|..||....||.||:|||.....:......:.|:
Zfish   130 YVGRQSFV-TEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNFFIGVTGI 193

  Fly   220 IRSLSSNYSMFLVFEFL-------DMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEA 277
            :.:.|.||...|||..|       ...||       ::|..||||...|........:|:::|..
Zfish   194 LVATSPNYISLLVFRALFGFGVKGGWMVG-------YVLITELVGVDHRRTVGVTYQLFFSMGIL 251

  Fly   278 FLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLP 342
            .|..||..:.:||||..|...|.:..:.:.|.:|||.||||:|....:|..:.:..|:.|::.|
Zfish   252 LLPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTL- 315

  Fly   343 EEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLC--WFTHTLIALGLSLNSVNLGGN 405
            .:::..|...|....|.|:     .|.......||.....|.  |||..::..||.:....||||
Zfish   316 SKKIETLKDDNIDSGSTAS-----FMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGGN 375

  Fly   406 KYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLC-ASMLLCAICMGASAAVPADNYAGSLALFLIG 469
            .|.:|:::|.:::|...|.|:.::|:|||.... |:::..|.|: .:|.:|...:....|:..:|
Zfish   376 VYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACL-ITAFIPDSMFWLKSAVACVG 439

  Fly   470 KLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAP-QTPLLAKYYIYAPQILFATFA 533
            :|.||.:|:::.|..:|::||.:||..:|:||.:..:|.::|| ....||..::..|.|:|...|
Zfish   440 RLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGALA 504

  Fly   534 LISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571
            .::|.|.|..|||....||.||::....|:.|...::|
Zfish   505 FVAGGLVLLLPETKGVPLPETIDDIEHPNRNKENPQQS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	147/530 (28%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	116/393 (30%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	147/530 (28%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	112/382 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030