Protein Alignment CG7458 and SLC22A10

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001034841.3
• Gene: SLC22A10 / 387775
• HGNCID: 18057
• Length: 541
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 140/569 - (24%)
• Similarity: 247/569 - (43%)
• Gaps: 63/569 - (11%)

  Fly    37 SLDAILVRIGQFGRYQIINYV------LLCVP--MLFNAFFSISYVFTASTVVHRCTVPQCD--- 90
            :.:.:|.::|..||:|:::.|      :|.:|  :|.|        |.|:...|||.|...|
Human     2 AFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLEN--------FAAAIPGHRCWVHMLDNNT 58

  Fly    91 ---SPSSVYEED-WLGFTIP-KKNSAWDDCHRYA------ANISDAISGYTDPSGQYCL------ 138
               :.:.:..|| .|..:|| ..|...:.|.|:.      .:::..|...::...:.|:
Human    59 GSGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGWVYD 123

  Fly   139 KEYFTITSETCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGR 203
            :.||                ..||.|::.:.|:.:...|:|..:...|..||..:||:.:||:||
Human   124 QSYF----------------PSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGR 172

  Fly   204 RTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATII 268
            |.:|.......|:.....:.:..:.::.|..||.......:.....|...|.:.|..:.....:.
Human   173 RFILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILS 237

  Fly   269 TIFYALGEAFLGFLASQVQHWRWLLRVLYAP-AVLQILFLWILPESVRWLLSQGAEEKASNVLRR 332
            :...::|:..||.||...:.|:.|..|...| .|..:|..|:: ||.|||:.....::....||:
Human   238 SGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLV-ESARWLIITNKLDEGLKALRK 301

  Fly   333 AARINQRPLPEEQLN-DLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLCW--FTHTLIALG 394
            .||.|.....||.|| :::.|..|:...|.:::..:.......|:|...|.|.:  |.:|:...|
Human   302 VARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYG 366

  Fly   395 LSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPAD-- 457
            ..:|..::|.|.:...:|.|.:.:....|.|:.::.:|||.|....|.|..:.:.|:..||.:
Human   367 TMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEMQ 431

  Fly   458 NYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYI 522
            ....:||...||..|.|.|...::|.  |:.||.:|.....:.....|||:.|||....|..::.
Human   432 TLRVALACLGIGCSAATFSSVAVHFI--ELIPTVLRARASGIDLTASRIGAALAPLLMTLTVFFT 494

  Fly   523 YAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571
            ..|.|::..|.:|.|.:....|||.:..||.||::..  ||.|...|::
Human   495 TLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE--NQKKNLKEKA 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	133/541 (25%)
		MFS	161..544	CDD:119392	100/388 (26%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	133/541 (25%)
		MFS	143..516	CDD:119392	96/375 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940