DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and SLC22A25

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_016873173.1	Gene:	SLC22A25 / 387601	HGNCID:	32935	Length:	577	Species:	Homo sapiens

Alignment Length:	583	Identity:	138/583 - (23%)
Similarity:	240/583 - (41%)	Gaps:	89/583 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISY------VFTASTVVHRC--------TVPQCDS 91
            :|.::|..||:||:..|.|   ::||.   |.|      .|.|..:.|||        |:|..|
Human     6 LLDQVGGLGRFQILQMVFL---IMFNV---IVYHQTQLENFAAFILDHRCWVHILDNDTIPDND- 63

  Fly    92 PSSVYEEDWLGFTIP-KKNSAWDDCHRYA------ANISDAISGYTDPSGQYCLKEYFTITSETC 149
            |.::.::..|..:|| ..|...:.|.|:.      .:::......::|..:.|:.
Human    64 PGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVD---------- 118

  Fly   150 GRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADR-------------- 200
            |..:.......||.|::.:.||.:...|:...:...|..||..|.|:.:||
Human   119 GWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCD 183

  Fly   201 ----------------YGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAF 249
                            :||:.:|..:....|::|...:.:....::....||..|...::.....
Human   184 EGLEVPIAIHQHHVFWFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTV 248

  Fly   250 LLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESV 314
            ||.:|.:..:....|.|:.....::|...||.||..::....|..|:.||..:..||...|.||.
Human   249 LLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESA 313

  Fly   315 RWLLSQGAEEKASNVLRRAARINQRPLPEEQLN-DLLTSNRQKLSQANESQYPIMRAVVFFSLRI 378
            |||:.....|:....||:||..|.....|:.|. ::|.|..::..:|.:.::.:...     |||
Human   314 RWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCEL-----LRI 373

  Fly   379 ANCC--LCW-----FTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHS 436
            .|.|  :|:     |..|:...||:|:..:||.|.:....|.|.:.:....:....::.:.||.|
Human   374 PNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLS 438

  Fly   437 LCASMLLCAICMGASAAVPADNYAGSLALFLIG----KLAITCSFQILYFFTSEIFPTNVRNTLL 497
            ....|.|.|.|:.|...||.:.....:.|..:|    .|.||||..    ..:|:.|:.:|....
Human   439 QMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTA----QENELIPSIIRGRAT 499

  Fly   498 SLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEARD 560
            .:......||..||....:|:.|....|.|::..||::||.:.|..|||.::.|..:|::..:
Human   500 GITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	136/570 (24%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	103/424 (24%)
SLC22A25	XP_016873173.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940