DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	567	Identity:	152/567 - (26%)
Similarity:	248/567 - (43%)	Gaps:	68/567 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVP-QCDSPSSVYEEDWL 101
            |||    :|..||:|::...||.:|....|..:....|||:...|.|..| ....|::.....||
Mouse     7 LDA----LGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEPTTNVSGVWL 67

  Fly   102 GFTIP-KKNSAWDDCHRYAANISDAISGYTDPSGQYCL----KEYFTITSETCGRDFKFRDEE-- 159
            ...|| .::...:.|.|           |.:|  |:.|    .....:.:|.| :|....|..
Mouse    68 RAAIPLNQHGDPEPCRR-----------YVEP--QWALLKPNASSHGVATEGC-KDGWVYDRSIF 118

  Fly   160 -KTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRT-------MLAVAGSVSAL 216
             .||..|:.:.||......:..:|...|..||..|.|..|||.||:.       .|||:|:.:|.
Mouse   119 PSTIVMEWDLVCEARTLRDLAQSIYMSGVLVGAALFGGLADRLGRKAPLVWSYLQLAVSGAATAY 183

  Fly   217 MGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGF 281
            :|       ::|.:.||.||.....|.:...:..|.:|.:..:.|..|..::...:.||:..|..
Mouse   184 VG-------SFSAYCVFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAG 241

  Fly   282 LASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQL 346
            :|..::.||||...:.||.::..|:.|.||||.||||..|..::|...|::.|.:|.|....|:|
Mouse   242 VAYLIRPWRWLQFAVSAPFLVFFLYSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGERL 306

  Fly   347 ---------NDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCL--CWFTHTLIALGLSLNSV 400
                     .|...|.|...|..:..:.|.:|.|        .|||  .||::::...||:::..
Mouse   307 TTEVVSSYIQDEFASVRTSNSILDLFRTPAIRRV--------TCCLMGVWFSNSVAYYGLAMDLQ 363

  Fly   401 NLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLAL 465
            ..|.:.|....|.|.|.||.:|:....|..||||.::.:.::|..:.:.|:..:|.|........
Mouse   364 KFGLSIYLVQALFGIIDIPAMLVATTTMIYVGRRATVSSFLILAGLMVIANMFMPEDLQTLRTVQ 428

  Fly   466 FLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFA 530
            ..:||..:..||..:|.||.|::||.:|...:...|:..|:|.::||....|.:.....|.:.|.
Mouse   429 AALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVNARLGGLVAPLITTLGEISPVLPPVSFG 493

  Fly   531 TFALISGFLTLAF-PETADKVLPTTI-------EEARDLNQAKRRSE 569
            ..::::|.....| .||.:..|..||       ::.|.....:::||
Mouse   494 ATSVLAGMAVACFLTETRNVPLVETIAAMERRVKQGRSKRDTEQKSE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	144/535 (27%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	112/401 (28%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	144/535 (27%)
		MFS	138..507	CDD:119392	106/383 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556		3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960