DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and CG4630

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	215/573 - (37%)
Similarity:	317/573 - (55%)	Gaps:	64/573 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDS-PSSVYEEDWLG 102
            |.|||.||:|||:|..||:|:|:|:||.|..|:||||||.:..:||.||:||. ..:.|..:|:.
  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWVS 80

  Fly   103 FTIPKKNSAW--------DDCHRYAANISDAISGYTDPSGQY----CLKEYFTITSETCGRDFKF 155
            ..:|   .:|        ..|.|:.|| .|.:...:||...:    |..|.||..:|.|.: |.:
  Fly    81 IAVP---GSWSKRGHFTPSTCERFVAN-GDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-FVY 140

  Fly   156 RDEEKTISTEFGIYC-EDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGV 219
            ...|:||..::|:.| |:.|||:.||||:..|..||..|.||.||||||:.:........||.||
  Fly   141 GSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTGV 205

  Fly   220 IRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLAS 284
            .::||.:|..||.|..|:....|.::|.||::.:|:|||::|..::.::..|||:|||.|| |:.
  Fly   206 AQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALLG-LSV 269

  Fly   285 QVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDL 349
            .:..||.|...|..|.::.:.:.|::||||||||::...|:|..::||||::|:|.:..|    |
  Fly   270 FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDISVE----L 330

  Fly   350 LTSNRQKLSQANESQ--------------------YPIMRAVVFFSLRIANCCLCWFTHTLIALG 394
            :.|.:|:...|...|                    ..:.|:.:... |.|...|.|..:.::..|
  Fly   331 MASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMG-RYAILLLIWAVNAIVYYG 394

  Fly   395 LSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAV----- 454
            ||||:.:|.||||.||.|...::|||..|..:.:.|.|||.:|..|:|||:|...||..|
  Fly   395 LSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQG 459

  Fly   455 ---PADNYAGS-----------LALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGR 505
               |......|           :.|||:|||.||.||.::|.||:|:.||.:|:..:.:.|...|
  Fly   460 DWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFAR 524

  Fly   506 IGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEA 558
            .|:||||..||||.||...|.:||.|.:|::|.|:|..|||.::.||.|:|||
  Fly   525 FGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	206/560 (37%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	156/422 (37%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	206/560 (37%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	137/380 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472740
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35816at33392
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106230
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900