Protein Alignment CG7458 and Slc22a14

DIOPT Version :10

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001101663.2
• Gene: Slc22a14 / 316061
• RGDID: 1306470
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 142/586 - (24%)
• Similarity: 257/586 - (43%)
• Gaps: 111/586 - (18%)

  Fly    35 DNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVF--TASTVVHRCTVPQCDSP----- 92
            |:...::|..||:||.:|.....|..:|.:.:.||.:|:.|  ||..       |.|::.
  Rat    48 DDKFASVLGAIGEFGTFQWRLVALTFIPSILSTFFLLSHHFLLTAQR-------PYCNTSWILQV 105

  Fly    93 -SSVYEEDWLGFTIPK-KNSAWDDCHRYAANISDAIS------GYTDPSGQYCLKEYFTITSETC 149
             .::.|::.|..|:|: .|.::..|..|.....|..|      .||                |||
  Rat   106 GPNLTEDEQLNLTVPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYT----------------ETC 154

  Fly   150 --GRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGS 212
              |..:.|. ..::::.||.:.|.:|.......|:...|...|..|.|:.:|:.||..::.:
  Rat   155 KHGWIYPFA-HTRSLTNEFDLVCGNEPHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIILL--- 215

  Fly   213 VSALMGVI-----RSLSSNYSMFLVFEFL--DMAVGSTLFPTAFLLAIELVGPKRRVAAATIITI 270
              :|:|::     .:..:::..:|.|.|.  ..:||..:...:  |.:|.:..:.|..|..:...
  Rat   216 --SLLGILIFGFGTAFVNSFYQYLFFRFFVAQASVGYAICSVS--LVMEWLVGEHRAQAIILQHC 276

  Fly   271 FYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAAR 335
            |:.:|...|...|.::.|||.|..:...|....|..:|:|.||.|||:.:|..|:|..||..||.
  Rat   277 FFTIGVILLTGFAYKINHWRLLFLLGGVPMFPLICNIWVLQESPRWLMVKGKVEEAKKVLCYAAE 341

  Fly   336 INQRPLPEEQLNDL-LTSNRQKLS----QANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGL 395
            :|::.:|...||:| |...:.|.|    ..|:..:.::.|:        .|  .|||.:.::|.|
  Rat   342 VNKKTIPLNLLNELQLPGKKAKASILDFYTNQHLFKVVLAM--------GC--VWFTVSYVSLTL 396

  Fly   396 SLNSVNLGGNKYTNFMLNGFIQ-------IPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAA 453
            ||...:.|.:.|       |||       :|..|..:::::..||:.||..::.|......:...
  Rat   397 SLKMKDFGLDIY-------FIQVVPCITAVPARLCCILLLEYFGRKWSLNLTLSLVTFTCLSLLF 454

  Fly   454 VPADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSM---VGRIGSM-----L 510
            ||.:..:.::.:.::|:.::..:..|.:.:|:|:.||.:|:|.|.:.|:   .|.|.|:     .
  Rat   455 VPEELKSTTILMLVLGEFSMAGTVSIFFIYTAELLPTILRSTGLGMVSIAWTAGAISSLAIFKQT 519

  Fly   511 APQTPLLAKYYIYAPQILFATFALISGFLTLAF----PETADKVLPTTIEE-ARDLNQAKRRSER 570
            ..|.|:.              |..:...|.|.|    |||.::.|..:||. :||..:.|.:|:.
  Rat   520 KTQLPIF--------------FCCLCCILALCFSSLVPETGNQPLRDSIEYCSRDSLEHKDKSKD 570

  Fly   571 S 571
            |
  Rat   571 S 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	MFS_SLC22	150..544	CDD:340875	100/424 (24%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:475125	101/434 (23%)