DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	144/534 - (26%)
Similarity:	228/534 - (42%)	Gaps:	69/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IGQFGRYQIINYVLLCVPM-LFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDW-LGFTIPK 107
            :|:.|.||:....||.|.: |:.|..:|......:|..:.                | :...:|.
  Rat    10 VGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYH----------------WDMAELLPN 58

  Fly   108 KNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEEKTISTEFGIYCED 172
            ::.            |:..||.....|.:.|    |.......:...|.:...:|::|:.:....
  Rat    59 QSH------------SNQSSGKGQAFGDWLL----TANGSEIHKHVHFSNSFTSIASEWFLIANR 107

  Fly   173 EWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLD 237
            .:|:|...:....|.|||:...|..:||:||:.:.....::..|..:....|.:|..|.|..||.
  Rat   108 SYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLV 172

  Fly   238 MAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAVL 302
            ..:...:...||:|..|.||......|.:|..:|:|:|.|....|...::.||.|..::.....:
  Rat   173 GMMNGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTV 237

  Fly   303 QILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLSQANESQYPI 367
            ..|....:|||.|||.|||...:|...|...|:.|::          |.........||.|....
  Rat   238 VFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK----------LKCTFSLTHPANRSYRET 292

  Fly   368 MRAVVFFSLRI-----ANCCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVI 427
            ...:..|..|:     ......||..:|:..||:|::.:|||:.|.|..|:|.|:||...|.:.:
  Rat   293 GSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYL 357

  Fly   428 MDR--VGRRHS----LCASMLLCAICM--------GASAAVPADNYAGSLALFLIGKLAITCSFQ 478
            :::  .||:.:    ||...|.|.|.|        |..|.|      .|.:|.|:|||.|:.:|.
  Rat   358 INQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVV------NSHSLSLLGKLTISAAFN 416

  Fly   479 ILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAF 543
            |:|.:|||::||.:||..|..|||..|:|.::||..|.|.......|.|:|....|.||.|:|..
  Rat   417 IVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPSLKDVQWSLPFIVFGATGLTSGLLSLLL 481

  Fly   544 PETADKVLPTTIEE 557
            |||.:..|..|..:
  Rat   482 PETLNSPLLETFSD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	143/528 (27%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	119/401 (30%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	111/373 (30%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	104/354 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930