DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	564	Identity:	160/564 - (28%)
Similarity:	272/564 - (48%)	Gaps:	52/564 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGF 103
            |.::..:|::|.:|.:.:.||...::.|.|..:|.||.|.|..|||.||...:.||    .|...
Mouse     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSS----SWRNH 65

  Fly   104 TIPKK----NSAWDDCHRY-AANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEE---K 160
            :||.:    ......|.|| .|.|::..:...:|.....|::   :..|:|...::: |::   .
Mouse    66 SIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQ---LEQESCLDGWEY-DKDIFLS 126

  Fly   161 TISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSS 225
            ||.||:.:.|||:||..:..::..||...|..:.|..:||:||:.:|....:|......::..|:
Mouse   127 TIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFST 191

  Fly   226 NYSMFLVFEFLDMAVGS-TLFPTAFLLAIELVGPKRRVAAATI-ITIFYALGEAFLGFLASQVQH 288
            |:.||.|. |..:.:|. :.:..||:|..|::....|:..:|: :..|:|:|...|...|..::.
Mouse   192 NWEMFTVL-FAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAYFIRD 255

  Fly   289 WRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQ--------RPLPEEQ 345
            ||.||..|..|.:..:...|.:|||.|||:||....:|..::::||::|.        .||..::
Mouse   256 WRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDPLELQE 320

  Fly   346 LNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIAN----CCLCWFTHTLIALGLSLNSVNLGGNK 406
            ||.|             .|..::...:|.:..||.    ..:.|...::....||||..||.|:.
Mouse   321 LNSL-------------KQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDV 372

  Fly   407 YTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKL 471
            |.|..|:|.|::|......:::..:.||:.:...:......:.....||.|....|:.|.::||.
Mouse   373 YLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGKF 437

  Fly   472 AITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALIS 536
            .||.:|.:||.||:|::||.|||..:.:.||..|:||::||....|..|....|.||..:..::.
Mouse   438 GITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLI 502

  Fly   537 GFLTLAFPETADKVLPTTIEE---ARDLNQAKRRS-----ERSP 572
            |.:||.|||:....||..:|:   .|.....|:.:     |.||
Mouse   503 GIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSVDREESP 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	153/529 (29%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	116/396 (29%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	152/528 (29%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	116/400 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.980