DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a17

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_803156.2	Gene:	Slc22a17 / 305886	RGDID:	631405	Length:	520	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	133/554 - (24%)
Similarity:	217/554 - (39%)	Gaps:	121/554 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VFTASTVVHRCTVPQCDSPSSVYEE--DWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQY 136
            :||.:..:| |........:|.:|:  :..|.::.....|.....|...:...:.||:..|...:
  Rat     6 IFTLAPPLH-CHYGALPPNASGWEQPPNSSGVSVAGAALAASAASRVVTSTDPSCSGFAPPDFNH 69

  Fly   137 CLKEYF-----TITSETCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGY 196
            |||::.     .:|:...|              ::.:.|:..|::.:...:..:|...|....||
  Rat    70 CLKDWDYNGLPVLTTNAIG--------------QWDLVCDLGWQVILEQILFILGFASGYLFLGY 120

  Fly   197 FADRYGRRTML--------------AVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPT 247
            .|||:|||.::              |.|||.:.:|      :..:.:..:...:|:.|
  Rat   121 PADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIM------TLRFLLGFLLAGVDLGV------- 172

  Fly   248 AFLLAIELVGPKRRVAAATIITIFYALGE-AFLGFLASQVQHWRWLLRVLYAPAVLQILFLW--I 309
             :|:.:||..|.:|:..|....:....|. .||| ||...:.||:|.|::.||.:|.:.:.|  :
  Rat   173 -YLMRLELCDPTQRLRVALAGELVGVGGHFLFLG-LALVSKDWRFLQRMITAPCILFLFYGWPGL 235

  Fly   310 LPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFF 374
            ..||.|||:.:...|:|.:|||..|..|:   |..|   :|....|:..|..|:..|:.....|.
  Rat   236 FLESARWLIVKRQIEEAQSVLRILAERNR---PHGQ---MLGEEAQEALQELENTCPLPTTSTFS 294

  Fly   375 SLRIANCCLCWFTHTLIALGLSLNSVNL-------------GGNKYTNFMLNGFIQIPGLLLPLV 426
            ...:.|....|  ..|:.||.:    |.             ||...::|.|...:......|..|
  Rat   295 FASLLNYRNIW--KNLLILGFT----NFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACV 353

  Fly   427 IM----DRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIG------KLAITCSFQILY 481
            .:    ||.|||..|..||.|                .|..:|.|:|      ..||| :|.:|.
  Rat   354 FLGVTVDRFGRRGILLLSMTL----------------TGIASLVLLGLWDYLNDAAIT-TFSVLG 401

  Fly   482 FFTS------------EIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFAL 534
            .|:|            |:.||.||...|.|...:|.:|.:..|...|...:..:...::.|..||
  Rat   402 LFSSQASAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHMGHGAFLQHVVLAACAL 466

  Fly   535 ISGFLTLAFPETADKVLPTTIEEARDLNQAKRRS 568
            :.....:..|||..|:||   |..||....:|.|
  Rat   467 LCILSIMLLPETKRKLLP---EVLRDGELCRRPS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	128/538 (24%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	105/434 (24%)
Slc22a17	NP_803156.2	MFS	106..476	CDD:119392	103/413 (25%)
Slc22a17	NP_803156.2	2A0114	111..475	CDD:273326	102/407 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100