DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Sv2c

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_113781.1	Gene:	Sv2c / 29643	RGDID:	619718	Length:	727	Species:	Rattus norvegicus

Alignment Length:	688	Identity:	129/688 - (18%)
Similarity:	217/688 - (31%)	Gaps:	270/688 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DSPSSVYEEDWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSG-QYCLKEYFTITSETCGRDF 153
            |....:||.::.|  ||..|..           .|:|.....|.| :|  |:...:.||.
  Rat    83 DEEDEIYEGEYQG--IPSTNQG-----------KDSIVSVGQPKGDEY--KDRRELESER----- 127

  Fly   154 KFRDEEKTISTEFGIYCED------EWKLSMV--------------------------------- 179
              |.:|:.::.::.:..::      :|.|..|
  Rat   128 --RADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGS 190

  Fly   180 ---GTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLD-MAV 240
               |:|..:|..||....|..||:.||:..|.:..||:.....:.|....|..||:...|. ..:
  Rat   191 GWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGI 255

  Fly   241 GSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFL----------------ASQVQHW 289
            |..: ||.|....|::..::|....:.:.:|:.:|..:...:                |.|...|
  Rat   256 GGAI-PTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSW 319

  Fly   290 RWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRP--LPEEQLNDLLTS 352
            |..:.|...|.|..::.|..:|||.|:||..|..::|..:|:.....|.|.  .||:    :.|.
  Rat   320 RVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEK----VFTV 380

  Fly   353 NRQKL-SQANE---------------------------------SQYPIMRAVVFFSLRIANCCL 383
            |:.|. .|.:|                                 ..||:....:       ...:
  Rat   381 NKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTI-------KLTI 438

  Fly   384 CWFTHTLIALGLS----------------LNSVNLGGNKYTNFMLN------------------- 413
            .|||.:....|||                |.:.|:..:||.||.:|
  Rat   439 VWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFL 503

  Fly   414 ---------------------------------------------------------GFIQ---- 417
                                                                     .|:.
  Rat   504 GVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTG 568

  Fly   418 -------------------------IPGLLLPLVIMDRVGRRHSLCASMLLCAI-C----MGASA 452
                                     :||.::..::|||:||...|..||:|..| |    .|.|.
  Rat   569 CQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE 633

  Fly   453 AVPADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNT----LLSLCSMVGRIGSMLAPQ 513
            ::    ..|.|.|:  ..|.|: ::..|...|.|::||:.|.|    |.:||.....:|:::...
  Rat   634 SM----MIGMLCLY--NGLTIS-AWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGS 691

  Fly   514 TPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVL 551
            ...:.|   ..|.:|.:|..:..|.:.|..|:|..:||
  Rat   692 LVSITK---AIPILLASTVLVCGGLVGLRLPDTRTQVL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	129/688 (19%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	108/607 (18%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	129/688 (19%)
		Interaction with SYT1. /evidence=ECO:0000269\|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..120		13/51 (25%)
		MFS	155..719	CDD:119392	106/585 (18%)
		Pentapeptide_3	507..561	CDD:290309	0/53 (0%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:16543415, ECO:0000269\|PubMed:27294781	529..566		1/36 (3%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910