DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	157/564 - (27%)
Similarity:	264/564 - (46%)	Gaps:	54/564 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NSLDAILVRIGQFGRYQIINYVLLCVPMLFNAF--FSISYVFTASTVVHRCTVPQCDSPS----- 93
            :::|.||..||:|..:|...:.||.  :|..||  ..:..||...|..|.|..|.....|
  Rat     2 STVDDILEHIGEFHLFQKQTFFLLA--LLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQRCGW 64

  Fly    94 SVYEEDWLGFTIP-----KKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDF 153
            |..||  |.:|:|     .:.|....|.||..:.:.:.....||..... .:...:....|...:
  Rat    65 SQAEE--LNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLA-ADRNQLPLGPCEHGW 126

  Fly   154 KFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMG 218
            .:.....:|.|||.:.|...|.|.:..::.|||.|:|..:.||.|||:||:..|.|...::|:.|
  Rat   127 VYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAISG 191

  Fly   219 VIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLA 283
            .:.::|.||:..|||.||...|....:...::|..|.||...|........|.:.:|...|..:|
  Rat   192 ALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGICYQIAFTVGLLILAGVA 256

  Fly   284 SQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLND 348
            ..:.:||||...:..|....:|:.|.:|||.|||:||....||..:::..|:.|.:.:|....|
  Rat   257 YVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVSLQN- 320

  Fly   349 LLTSNRQKLSQANESQYPIMRA--------VVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGN 405
             ||.:.....:...|...::|.        ::.::         |||.:::..||.::....|.|
  Rat   321 -LTPDEDAGKKLKPSILDLVRTPQIRKHTLILMYN---------WFTSSVLYQGLIMHMGLAGDN 375

  Fly   406 KYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCAS-MLLCAICMGASAAVPADNYAGSLALFLIG 469
            .|.:|..:..::.|...:.::.:||||||:....| |:..|.|: ||..:|.|.....:.:..:|
  Rat   376 IYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACL-ASVFIPDDLQWLKITIACLG 439

  Fly   470 KLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYA--------PQ 526
            ::.||.:::::....:|::||.:||..:.:||.:..||.::.|       :.:|.        |.
  Rat   440 RMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITP-------FLVYRLTDIWMEFPL 497

  Fly   527 ILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSER 570
            ::||...|::|.|.|..|||..|.||.|||:|.:: |..|:.||
  Rat   498 VVFAVVGLVAGALVLLLPETKGKALPETIEDAENM-QRPRKKER 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	145/536 (27%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	111/399 (28%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	145/536 (27%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	104/385 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030