Protein Alignment CG7458 and SLC22A24

DIOPT Version :9

• Sequence 1: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001129978.2
• Gene: SLC22A24 / 283238
• HGNCID: 28542
• Length: 552
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 140/565 - (24%)
• Similarity: 247/565 - (43%)
• Gaps: 61/565 - (10%)

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYV----------FTASTVVHRCTVPQCDSPS 93
            |.:|.::|..||:||      |:    .|||.|:.:          |||.|..|||.||..|:.:
Human     4 DVLLDQVGGMGRFQI------CL----IAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDT 58

  Fly    94 -------SVYEEDWLGFTIP-KKNSAWDDCHRY------AANISDAISGYTDPSGQYCLKEYFTI 144
                   ::.::|.|..:|| ..|.....|.|:      ..:::.......:|..:.|:..:...
Human    59 VSDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYD 123

  Fly   145 TSETCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAV 209
            .|...          .||.||:.:.||.:...|||.::...|..:|..:.|:.:||.||:.:..:
Human   124 RSSFL----------STIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKL 178

  Fly   210 AGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYAL 274
            .....|:.....:.:..:.::.:..||......|:....|:|::|...|:.|.....::...|::
Human   179 CFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSV 243

  Fly   275 GEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQR 339
            |:..||.||..:|.|..|...:..|.::..|..|.:.||.|||:.....::....|||.|.||.:
Human   244 GQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGK 308

  Fly   340 PLPEEQL-NDLLTSNRQKLSQA---NESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSV 400
            ...||.| .:|:.|..:|...|   ..|.:.:.||.. ..:|:...|...|..|:...||.||..
Human   309 KNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPK-LRMRVFGLCFVRFAITVPFYGLILNLQ 372

  Fly   401 NLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMG----ASAAVPADNYAG 461
            :||.|.....:|.|.:......:.|:.::.:|||    .|.:|....:|    .:..:|.:....
Human   373 HLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRR----ISQILFTFPVGLFILVNTFLPQEMQIL 433

  Fly   462 SLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQ 526
            .:.|..:|..:::.:........:|:.||.:|:|:..:.::.||.|:.|||....|..|..:.|.
Human   434 RVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPW 498

  Fly   527 ILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571
            |.:..|.:::..:.|..|||.|..||.||::..:    .|:..|:
Human   499 ISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN----DRKDSRN 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	134/539 (25%)
		MFS	161..544	CDD:119392	98/390 (25%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	101/421 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950