DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a29

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	572	Identity:	136/572 - (23%)
Similarity:	247/572 - (43%)	Gaps:	65/572 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYV----FTASTVVHRCTVPQCDSPSS--- 94
            |...:|.::|..||:||:..|.|   .|.||.. :.::    |||:...|||.||..|:.::
Mouse     2 SFQELLNQVGSLGRFQILQIVFL---FLLNAIV-VPHIGMENFTAAIPNHRCWVPILDNDTASDN 62

  Fly    95 ----VYEEDWLGFTIP-KKNSAWDDCHRYA------ANISDAISGYTDPSGQYCLKEYFTITSET 148
                :.::|.|..:|| ..|...|.|.|:|      .:::...|..::|..:.|:..:....|..
Mouse    63 GSRILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNF 127

  Fly   149 CGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSV 213
            .          .||.||:.:.||.:...|:......:|.|:|..:.|:.:||:||:.:|..|...
Mouse   128 L----------STIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQ 182

  Fly   214 SALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFP---TAFLLAIELVGPKRRVAAATIITIFYALG 275
            .|:.....:.:.::.::....||   .|.::.|   .:.||.:|...||.....|.:.:....:|
Mouse   183 FAITETCVAFAPSFFIYCSLRFL---AGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIG 244

  Fly   276 EAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARIN-QR 339
            ...|..||...:.|..|...:.||....::....|.||.|||:.....:|....||:.|.:| .:
Mouse   245 FMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMK 309

  Fly   340 PLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLCWFTH---TLIALGLSLNSVN 401
            ...:..:..:.||.:.:|..|...  |.:|.:...|:.....|:..|..   |:..:||:::..:
Mouse   310 NSGDLTMEIVRTSMKAELEAAKTK--PSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQH 372

  Fly   402 LGGN-KYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPAD-------- 457
            |..| ....|:::....:..::.|.| ::.:|||.:....|.|..|.:..:..||.:
Mouse   373 LSSNIILLQFLISALAILVSVIGPFV-LNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTLRIIM 436

  Fly   458 -NYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYY 521
             ..||.::...:|         :.:..|:|:.||.:|.|.|.:....|..|..|:|...|:|.||
Mouse   437 ATLAGGISSLCVG---------VSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYY 492

  Fly   522 IYAPQILFATFALISGFLTLAFPETADKVLP-TTIEEARDLNQAKRRSERSP 572
            ...|.|.:..|::.:.|.....|||.::.|| :|.:...|..::::.....|
Mouse   493 ANLPWIFYGGFSIFNAFTVFLLPETKNQPLPDSTHDVGNDWKESRKGKREDP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	131/543 (24%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	94/399 (24%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	97/430 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940