DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	566	Identity:	140/566 - (24%)
Similarity:	243/566 - (42%)	Gaps:	65/566 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSS-------VYEE 98
            :|..:|..||:||:....|.:..:......|...|||:.:.|||.|...|:.::       :.::
Mouse     6 LLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSGILSQD 70

  Fly    99 DWLGFTIP-KKNSAWDDCHRYA------ANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFR 156
            |.|..:|| ..|...:.|.|:.      ...:.:.|..|:|..:.|:.          |..:..|
Mouse    71 DLLRISIPLDSNLRPEKCRRFVQPQWHLLQFNGSFSNMTEPDTEPCMD----------GWVYDQR 125

  Fly   157 DEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIR 221
            ....|..||:.:.|..:...|:...|..:|...|..:||:.:|::||:.:...|....|:.|...
Mouse   126 TFLSTTVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQMAITGTCT 190

  Fly   222 SLSSNYSMFLVFEFLDMAVGSTLFP---TAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLA 283
            :|:..:.::.:..||   .|..:.|   .:.||.:|...||.:....|:....:..|...|..||
Mouse   191 ALAPTFFIYCLLRFL---TGLCIIPINTNSVLLMLEWTSPKTQALVTTLSMSSHHFGGLILAGLA 252

  Fly   284 SQVQHWRWLLRVLYAPAVLQILFLWILP------ESVRWLLSQGAEEKASNVLRRAARINQRPLP 342
            ...|:|..|...:..|     :|:.::|      ||.|||:.....:||...||:.|..|.....
Mouse   253 FAFQNWHHLQLAISVP-----IFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVASKNGIKNS 312

  Fly   343 EEQL---------NDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLN 398
            |:.|         .|.:...|.|.|..:....|.:|.      |:...||..|......:|:::|
Mouse   313 EDVLTMEVVRTIMKDEIAIPRTKPSLRDLFHMPNLRK------RLCLLCLLRFLQISPTVGINMN 371

  Fly   399 SVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSL 463
            ..:|.||.:....|.....||...|...:::.:|||.|.....||..|.:.:..:||.:  ..:|
Mouse   372 LQHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIFLLSIVSVPQE--MQTL 434

  Fly   464 ALFLI----GKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYA 524
            .:.||    |..|:..:..:||  :||:.||.:|.|.|.:..:.|.:|:.|:|...:|..|....
Mouse   435 LVVLITLAGGSSAMIYNSNVLY--SSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSASL 497

  Fly   525 PQILFATFALISGFLTLAFPETADKVLPTTIEEAR-DLNQAKRRSE 569
            |.|::...:::.|.|.|..|||.::.||.:|::.. ....:|::.|
Mouse   498 PWIIYGVLSILGGLLPLILPETKNQPLPDSIQDVECGWESSKQKKE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	136/543 (25%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	103/404 (25%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	105/424 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940