DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	563	Identity:	136/563 - (24%)
Similarity:	243/563 - (43%)	Gaps:	63/563 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSS-------VYEE 98
            ::::||..||:||::.:.:.:....:|..::...|||:...|||.||..|:.::       :.::
Mouse     6 LIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIPSHRCWVPILDNDTASDNGSRILSQD 70

  Fly    99 DWLGFTIP-KKNSAWDDCHRY------AANISDAISGYTDPSGQYCLK----EYFTITSETCGRD 152
            |.|..:|| ..|...|.|.||      ..:::......|:|..:.|:.    :..|..|.|.
Mouse    71 DLLRISIPLDSNLRPDKCRRYIQPQWHLLHLNGTFPTVTEPDTEPCVDGWVYDQSTFLSTTV--- 132

  Fly   153 FKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALM 217
                       |::.:.|..:...|:...|...|.|:|..:||:.:|::||:.:...:....|:.
Mouse   133 -----------TQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFTCSLLKMAIT 186

  Fly   218 GVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFL 282
            ....:.:.::.::....||.....|||...:.||.:|...||.:.....:|.|...:|:..||.|
Mouse   187 ETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIASGVGQTLLGGL 251

  Fly   283 ASQVQHWRWLLRVLYAPAVLQILFLWILP-----ESVRWLLSQGAEEKASNVLRRAARINQRPLP 342
            |...::|..|...|..|     :||.::|     ||.|||:.....:|:...|::||.:|:
Mouse   252 AFAFRNWHHLQLALSVP-----MFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACVNR---- 307

  Fly   343 EEQLNDLLT--------SNRQKLSQANESQYPIMRAVVFFSLRIANCCLCW--FTHTLIALGLSL 397
            .:...|.||        ....:.:|...|...:.|..   :||...|.|.:  |...:..|||.:
Mouse   308 IKNSGDALTLEVVKTIMKEELEAAQTKPSPLDLFRTP---NLRKRICLLSFVRFVSVMSLLGLLI 369

  Fly   398 NSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGS 462
            |...|..|.:....|.|.:.||..:|....|:.:|||.:....|.:..|.:.|...:|.:.....
Mouse   370 NIQYLSNNVFLLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEMQILR 434

  Fly   463 LALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQI 527
            :.|..:|....:.|........:|:.||.:|.|.|.:..:.|..|..|:|...:|..|....|.|
Mouse   435 VFLSTLGGAISSASITSTLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSASLPWI 499

  Fly   528 LFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSER 570
            ::.....:.|.:.|..|||.::.||.:|::..:    ||:|.:
Mouse   500 IYGILPFLGGLVALLLPETKNQPLPDSIQDIEN----KRKSSK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	131/540 (24%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	96/397 (24%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	130/539 (24%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843921
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940