DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus

Alignment Length:	560	Identity:	157/560 - (28%)
Similarity:	272/560 - (48%)	Gaps:	47/560 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SLDAILVRIGQFGRYQIINYVLLCVPMLFNAF--FSISYVFTASTVVHRCTVP-------QCD-S 91
            ::|.||..||:|..:|...:.||.  :|..||  ..:..||...|..|.|..|       :|. |
Mouse     3 TVDDILEHIGEFHLFQKQTFFLLA--LLSGAFTPIYVGIVFLGFTPNHHCRSPGVAELSQRCGWS 65

  Fly    92 PSSVYEEDWLGFTIPKKNSAWD-----DCHRYAANISDAISGYTDP-SGQYCLKEYFTITSETCG 150
            |:   ||  |.:|:|...||.:     .|.||..:.:.:.....|| |.....:.:..::  .|.
Mouse    66 PA---EE--LNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLPLS--PCE 123

  Fly   151 RDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSA 215
            ..:.:.....:|.|||.:.|...|.|.:..::.|||.|:|....||.|||:||:..|.|...::|
Mouse   124 HGWVYDTPGSSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLLVTILINA 188

  Fly   216 LMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLG 280
            :.||:.::|.||:..|||.||...|....:...::|..|.||...|........|.:.:|...|.
Mouse   189 ISGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIAFTVGLLILA 253

  Fly   281 FLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQ 345
            .:|..:.:||||...:..|....:|:.|.:|||.|||:||....||..:::..|:.|.:.:|...
Mouse   254 GVAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSL 318

  Fly   346 LNDLLTSNRQKLSQANESQYPIMRA--------VVFFSLRIANCCLCWFTHTLIALGLSLNSVNL 402
            .:  ||::.....:.|.|...::|.        ::.::         |||.:::..||.::....
Mouse   319 QS--LTADEDTGMKLNPSFLDLVRTPQIRKHTLILMYN---------WFTSSVLYQGLIMHMGLA 372

  Fly   403 GGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCAS-MLLCAICMGASAAVPADNYAGSLALF 466
            |.|.|.:|..:..::.|...:.::.:||:|||:....| |:..|.|: ||..:|.|.....:.:.
Mouse   373 GDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACL-ASVFIPDDLQWLKITVA 436

  Fly   467 LIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAP-QTPLLAKYYIYAPQILFA 530
            .:|::.||.:::::....:|::||.:||..:.:||.:..||.::.| ....|...::..|.::||
Mouse   437 CLGRMGITIAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFA 501

  Fly   531 TFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSER 570
            ...|::|.|.|..|||..|.||.|||:|..:.:.:::.|:
Mouse   502 VVGLVAGGLVLLLPETKGKALPETIEDAEKMQRPRKKKEK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	148/533 (28%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	111/392 (28%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	148/533 (28%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	104/378 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030