DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	547	Identity:	148/547 - (27%)
Similarity:	257/547 - (46%)	Gaps:	46/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTI 105
            ||.|:|..|.:|.::..||.:|:|..|..::..:|||:|..|.|..|    |::.. |.|:   :
Mouse     6 ILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPP----PNASL-EPWV---L 62

  Fly   106 P-KKNSAWDDCHRYA----ANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEEKTISTE 165
            | ..|...:.|.|:.    |::.:...|.|:|    ||..:.            :.....||.||
Mouse    63 PLGPNGKPEKCLRFVHLPNASLPNDTQGATEP----CLDGWI------------YNSTRDTIVTE 111

  Fly   166 FGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMF 230
            :.:.|.......|..::...|..||.|:.|..:||:||:.:|..:..:.|..|...:.|.:.:::
Mouse   112 WDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVY 176

  Fly   231 LVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRV 295
            ::|.||.....|.:..:..:|.:|.|....|..::|.|...|.:|:..|..||..|..||||...
Mouse   177 MIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLS 241

  Fly   296 LYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQL--NDL-------LT 351
            :.|...:..|..|.:|||:|||:..|...||...|:|.|..|.:....|:|  .:|       :|
Mouse   242 VSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKDIT 306

  Fly   352 SNRQKLSQANESQYPIMRAVVFFSLRIANC-CLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGF 415
            |.:.|...::..:..|:|.|.|       | .|.||........|::.....|.|.|...::.|.
Mouse   307 SAKVKYGLSDLFRVSILRRVTF-------CLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGG 364

  Fly   416 IQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQIL 480
            :.||...:.::.:..:|||.:....::|..:.:.|...|.::......||.:.||..::.||..|
Mouse   365 VDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCL 429

  Fly   481 YFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPE 545
            :.:|||::||.:|.|.:.:.::..|:|||:||...:..:...:.|.::|.|..|:.|.......|
Mouse   430 FLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLE 494

  Fly   546 TADKVLPTTIEEARDLNQAKRRSERSP 572
            |.::.||.|||:.:|..|..:::::.|
Mouse   495 TLNRPLPETIEDIQDWYQQTKKTKQEP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	139/522 (27%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	107/392 (27%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	139/522 (27%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537		1/9 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030