DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	148/568 - (26%)
Similarity:	245/568 - (43%)	Gaps:	67/568 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFF---SISYVFTASTVVHRCTVPQCDSPS-------SV 95
            :|.::|..||:||:....:   ::||...   |:...|||....|||.||..|:.:       ::
  Rat     6 LLNQVGSLGRFQILQMTFI---LIFNIIISPHSLLENFTAVIPNHRCWVPILDNDTVSGNDNGNL 67

  Fly    96 YEEDWLGFTIPKKNSAW-DDCHRYA------ANISDAISGYTDPSGQYCLKEYFTITSETCGRDF 153
            .::|.|..:||..:... :.|.|:.      .:::...|..|:|..:.|:             |.
  Rat    68 SQDDLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGTFSSVTEPDTEPCV-------------DG 119

  Fly   154 KFRDEE---KTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSA 215
            ...|:.   .||.||:.:.||.:...|:...:...|..||..|.|...||:|||.:|..|   |.
  Rat   120 WVYDQSTFLSTIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICA---SL 181

  Fly   216 LMGVIRSLSSNYSMFLVFEFLDMAVG---STLFPTAFLLAIELVGPKRRVAAATIITIFYALGEA 277
            .|.|..:.::....||::..|....|   ||:...:.||.||...||.:..|..::....|:|:.
  Rat   182 QMAVTETCAAFAPTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQT 246

  Fly   278 FLGFLASQVQHWRWLLRVLYAPAVLQILFLWI----LPESVRWLLSQGAEEKASNVLRRAARINQ 338
            .|..||..|::|..|...:..|    |.||.:    |.||.|||:.....:|....|.:.|.||.
  Rat   247 VLAGLAFTVRNWHHLHLAMSVP----IFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHING 307

  Fly   339 RPLPEEQLNDLLT--------SNRQKLSQANESQYPIMRAVVFFSLRIANCCLCW--FTHTLIAL 393
            .    :...|:||        ....:.||...|.:.:.|..   :||...|.|..  |...|..:
  Rat   308 M----KNSTDVLTIEVVRTIMKEELEASQTKSSLWDLFRTP---NLRKRICLLSLVRFVVWLSVI 365

  Fly   394 GLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADN 458
            ||.:|..:|..|.:....|.|.|.||..|:.:.:::.:|||.|....:.|..|.:.|...||.:.
  Rat   366 GLLINFQHLRINVFLLQCLLGIITIPANLVGIFLVNHLGRRISQLFIISLFGISILAIIFVPQEM 430

  Fly   459 YAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIY 523
            ....:.|...|.:....|........:|:.||.:|.|.|.:..:.|..|:.|:|...:|..|...
  Rat   431 QILRMVLATFGGVFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDS 495

  Fly   524 APQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571
            .|.|::...:.:.|.:.|..|||.::.||.:|::..:..:|.|:.:::
  Rat   496 LPWIIYGVLSFLGGLVVLLLPETKNQPLPDSIQDVENEGRASRQGKQN 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	144/544 (26%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	110/399 (28%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	143/543 (26%)
		Aldolase_II	39..>85	CDD:294146	13/45 (29%)
		MFS	125..506	CDD:119392	108/394 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940