DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and C06H5.6

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_507509.3	Gene:	C06H5.6 / 180170	WormBaseID:	WBGene00007394	Length:	556	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	137/564 - (24%)
Similarity:	237/564 - (42%)	Gaps:	54/564 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSQKEGNGYRRSDSKTTG----HADAEAATQTAGGDEDNSLDAILVRIGQFGRYQIINYVL-LC 60
            ||.:...:...||:|.:..    |.||               |.:|...|::||||::.||: ..
Worm     1 MTDEPSSSHPPRSNSMSATFNYLHLDA---------------DKVLTAFGKYGRYQMLAYVITTS 50

  Fly    61 VPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTIPKKNSAWDDCHRYAANISDA 125
            |.||| |...:...|...:|...|.:|..:|..|.:....:|          |.||.....::..
Worm    51 VHMLF-ALNMMIMPFITKSVEFLCDLPDPESIDSAHFSPLVG----------DSCHLQDTQLNIT 104

  Fly   126 ISGYTDPSGQYCLKEYFTITSETCGRDFKF-RDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFV 189
            |.         ||        ...|..:.: .|::.||:::|.:.||.:.......:|..||..:
Worm   105 ID---------CL--------AVNGASYNYLADKKSTITSDFDLVCEYQGMAEHATSIFLVGGMI 152

  Fly   190 GIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIE 254
            ..|.....:|..|||.:..:...:|....:|.:.:.||.:||:|.|:.....::...|.|:|.:|
Worm   153 VSPFVSQLSDILGRRPLFLIPLYISVAANLICAAAPNYLIFLLFRFISGVATTSFSMTGFVLCME 217

  Fly   255 LVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLS 319
            .|..:.|.....:.||.:..|....|......::||.|......|.:|.|.|.|..|||:.||::
Worm   218 SVSLEFRSLIPVLTTISWVGGYMLAGVFYVFFKNWRVLYFAASVPGLLTIPFFWFTPESLHWLMT 282

  Fly   320 QGAEEKASNVLRRAARINQRPLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCCLC 384
            :..:.|....:..:...|::.:......::.|.:....:....:...:....:|..:.|.:..|.
Worm   283 KQNDRKIKKYINESVAFNKQTISLIDCRNIQTVDNAPATTKTRTFRALFYPKIFVHVVINSFILI 347

  Fly   385 WFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMG 449
            ..:.|..|  |||.|..|..::.|.:.|:|.:::|...|.:.::....|:.....|:...|:.|.
Worm   348 VMSGTYWA--LSLYSTELSEDETTGYFLSGLVELPAGFLSVFLLIAFKRKTVSFYSLAFTAVFML 410

  Fly   450 ASAAVPAD-NYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQ 513
            .:..:|.. ||.....|......:|..:.|.|.:  ||..||.:||....:.|.||.:||:.||.
Worm   411 CTVYIPMQGNYKMIFPLLAKSTNSIVWASQPLLY--SEATPTTIRNVFSGVVSFVGELGSIGAPY 473

  Fly   514 TPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEE 557
            ...|......||.||.:..::::.||.|..|||.:|.||..:::
Worm   474 MNRLTAINQDAPAILISIMSIVAAFLVLLQPETKNKKLPEDLDQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	127/510 (25%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	94/383 (25%)
C06H5.6	NP_507509.3	MFS_SLC22	115..504	CDD:340875	95/392 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010