DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and F17C11.12

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_505789.1	Gene:	F17C11.12 / 179514	WormBaseID:	WBGene00008923	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	590	Identity:	135/590 - (22%)
Similarity:	234/590 - (39%)	Gaps:	100/590 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SDSKTTGHADAEAATQ----TAGGDEDNSL--DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSI 71
            :.|:.|...|.|.:.|    |..|...|::  |.:|    :.|||.|:..:.:.|.||.....::
Worm     2 TSSQKTEKCDNEESLQILEKTNTGTMYNTVHSDDLL----KMGRYSILLCIFVEVAMLSQLSNTM 62

  Fly    72 SYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQY 136
            ..|:..:..    |:..|.:           .|......|   |..|:                |
Worm    63 LMVYAGAAP----TIKSCGN-----------MTFSSNEEA---CLHYS----------------Y 93

  Fly   137 CLKEYFTITSETCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGT-INNVGQFVGIPLGGYFADR 200
            |.::          ::..|..:...|:.:|.:.|||. ||..:|| |..:|..:|..:.|...|:
Worm    94 CKEQ----------KEMTFERQFYGITEQFKLLCEDA-KLEKLGTSIQMLGVMLGCVVFGQIGDQ 147

  Fly   201 YGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAA 265
            |||:|.:.....:..:.|::.:||:::..|.:|..:...........:.:..||.:..:.|...:
Worm   148 YGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRTRGYIS 212

  Fly   266 TIITIFYALGEAFLGFLASQVQHWRWLLRV---LYAPAVLQILFLWILPESVRWLLSQGAEEKAS 327
            |:|:  |:.....||.||...|.|..|..|   |..||::.:.|   |.||.|||:.:|....|.
Worm   213 TLIS--YSPNVILLGILAFFFQQWDRLALVISFLTVPAIIMLAF---LHESPRWLMQKGQISHAK 272

  Fly   328 NVLRRAARINQRP----LPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIAN-------- 380
            .|.....:.:..|    |.|.:|.:.|.:...|  |..:....:.:...|:.|....
Worm   273 KVFLAIEKFDGVPAAKSLNETELENFLENEHDK--QVADGNTEVGKQHSFWHLFKTKEIMTGTFV 335

  Fly   381 CCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVI---MDRVGRR--HSLCAS 440
            ....:|..|||...:..|...:.|:.|.|.:|.|.::....|...::   .::..|:  |.:| |
Worm   336 IAFTFFATTLINYSIMFNLGAVAGSIYMNSILIGLLRYSFSLFSGLLDYKFEKFDRKMCHGIC-S 399

  Fly   441 MLLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQ-----ILYFFTSEIFPTNVRNTLLSLC 500
            ::..:|.:...|....|..|....|..||.| ::|:..     :....::|:.||.:|:...|..
Worm   400 VVTISIIVAIIAFCLTDTTATFSVLIRIGVL-LSCAMTSQAIIVASIASNELMPTAIRSISYSTA 463

  Fly   501 SMVGRIGSMLAPQTPLLAKYY-IYAPQILFATFALI--SGFLTLAF--PETADKVLPTTIEEARD 560
            .:..|.|.:.||....|..|. |..|.:.:|....|  :.|:...|  |||.:|.|...|
Worm   464 QLCSRFGIVFAPHVFHLNLYTGIDFPVLPYAILLAIGLADFIFFRFLIPETKNKPLEDFI----- 523

  Fly   561 LNQAK 565
            :|:.|
Worm   524 VNRTK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	122/538 (23%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	100/413 (24%)
F17C11.12	NP_505789.1	2A0119	<109..521	CDD:273328	105/421 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D762280at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020