DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and K05F1.6

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001342018.1	Gene:	K05F1.6 / 173977	WormBaseID:	WBGene00019408	Length:	858	Species:	Caenorhabditis elegans

Alignment Length:	605	Identity:	158/605 - (26%)
Similarity:	272/605 - (44%)	Gaps:	79/605 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KEGNGYRRSDSKTTGHADAEAATQTAGGDEDNSLDAILVRIGQFGRYQIINYVLLCVPMLFNAFF 69
            ::.|...|.:.|.|...|.|               .||..||....:||..|||:.:..:.:|.|
Worm   184 RDVNKKERKEGKPTDPIDFE---------------GILNIIGGCRWWQIWIYVLIALQQIPHAMF 233

  Fly    70 SISYVFTASTVVHRCTVPQCDSPSSVYEED-----W-------LGFTIPKKNS--AW--DDCHRY 118
            :::.|:.......:|.||..:..:......     |       :.|..|..||  |:  |.|:.|
Worm   234 NLNVVYMMYDPEFQCMVPGFNDTNDTTISSHGPYLWGVDDIKNISFVFPNANSDGAYQRDSCYFY 298

  Fly   119 AAN-----------ISDAIS-GYTDPSGQYCLKEYFTITSETCGRDFKFRDEEKTISTEFGIYCE 171
            ..:           :..|:| .:.|.:.:...:.|          .|:.....:||.|:|.:.|:
Worm   299 ERSEERYRQLRRMPLETAMSEAWKDVAPKKKCQAY----------HFEKDVMVETIVTDFNLVCD 353

  Fly   172 DEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFL 236
            ..:.........::|..:|..|||..:|:.||:..:...|.:|:::||....:..|.|||:...|
Worm   354 SWFAKGHAHMFYSIGYLLGCVLGGIASDKIGRKPTIIGFGILSSMLGVFLPFNDYYPMFLLIRLL 418

  Fly   237 DMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAV 301
            ...........|:.|.:|:.|.|.|....:::...:|||.|.|..:|...:.|:.:..:......
Worm   419 SAICNEAADLAAYTLCMEITGTKYRAMVGSMLQAPWALGYALLALIAYLTKSWKTIQVIAAGLHF 483

  Fly   302 LQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLN-----------DLLTSNRQ 355
            :.|:|:..:|||.|||:.|....:|..|:|:|.|  :.|.|.....           :|::...:
Worm   484 MSIIFICSIPESPRWLMVQNRVSEAEEVIRKACR--EPPFPFNMCTTSKCGNLPSDLELVSHRER 546

  Fly   356 KLSQANESQYPIMRAVVFFSL--RIANCCLCWFTHTLIALGL--SLNSVNLGGNK-YTN-FMLN- 413
            ||::.|..:...:.......|  |..:.|:.:....|:..||  :|:..:..|.. :|. |.||
Worm   547 KLNKKNGGKIGFLDLFTMKELRYRTISVCIVFMATALVYYGLVMALSDQSAPGRTLFTGYFHLNN 611

  Fly   414 ---GFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAI-CMGASAAVPADNYAGSLALFLIGKLAIT 474
               |.|:|| .|...|.|.::||:.:|..:::...: .:.|..::.:.:|..:||....||:|:.
Worm   612 GIAGAIEIP-TLFACVWMMQLGRKKALMLTLITSGLFIIVAMLSMVSGHYMLALAFMYFGKIAVQ 675

  Fly   475 CSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYI-YAPQILFATFALISGF 538
            .:|.|||.||||::||.||||.:.:.|||.|.||.|:....||:...: ..|.|:||.|:|.:|.
Worm   676 GAFNILYIFTSELYPTVVRNTAVGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAGM 740

  Fly   539 LTLAFPETADKVLPTTIEEA 558
            |....|||::|.||.|:::|
Worm   741 LVFVLPETSEKPLPETLDDA 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	147/558 (26%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	115/405 (28%)
K05F1.6	NP_001342018.1	MFS_SLC22	333..746	CDD:340875	117/425 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850