DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and SLC22A12

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_006718493.1	Gene:	SLC22A12 / 116085	HGNCID:	17989	Length:	578	Species:	Homo sapiens

Alignment Length:	582	Identity:	156/582 - (26%)
Similarity:	256/582 - (43%)	Gaps:	78/582 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPS-------SVYEE 98
            :|..:|..||:|::..:.|.|.:::....|:...|:|:...|||..|..|:.:       |:..|
Human     6 LLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPE 70

  Fly    99 DWLGFTIPK-KNSAWDDCHRY-------------AANISDAISGYTDP--SGQYCLKEYFTITSE 147
            ..|..:||. .|.....|.|:             |.:.|:|   .|:|  .|....:..||
Human    71 ALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEA---DTEPCVDGWVYDRSIFT---- 128

  Fly   148 TCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGS 212
                        .||..::.:.|:......|..:|...|..||....|..:||:|||.:|..:..
Human   129 ------------STIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYL 181

  Fly   213 VSALMGVIRSLSSNYSMFLVFEFL-------------------------DMAVGSTLFPTAFLLA 252
            ..|:||...:.:..:.::.:|.||                         .:..||...|...|..
Human   182 QMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAV 246

  Fly   253 IELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWL 317
            :|....:.|....|:.::.::.|......:|..|:.|..|..|:..|..|..|:.|.|.||.|||
Human   247 MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWL 311

  Fly   318 LSQGAEEKASNVLRRAARINQRPLPEEQLND--LLTSNRQKLS--QANESQYPIMRAVVFFSLRI 378
            |:.|..:.....|.|.|.||.:...::.|..  ||::.|::||  |...|...::|..   .||.
Human   312 LTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMP---GLRF 373

  Fly   379 ANC--CLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASM 441
            ..|  .||||.......||:|:...||.|.:...|..|.:.||..:..|:::..:|||.:|.||:
Human   374 RTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASL 438

  Fly   442 LLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRI 506
            ||..:|:.|:..||.:..|...||.::|...:..:|..:..::||:|||.:|.|.:.|..|..|.
Human   439 LLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG 503

  Fly   507 GSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRS 568
            |::|.|...||..:..:.|.:::.|..::||...|..|||....||.||::.:  |||.:::
Human   504 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQ--NQAVKKA 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	150/561 (27%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	115/413 (28%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	150/561 (27%)
SLC22A12	XP_006718493.1	MFS	122..541	CDD:119392	117/437 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960