DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7458 and SLC22A9

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_543142.2	Gene:	SLC22A9 / 114571	HGNCID:	16261	Length:	553	Species:	Homo sapiens

Alignment Length:	577	Identity:	143/577 - (24%)
Similarity:	235/577 - (40%)	Gaps:	86/577 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYV------FTASTVVHRCTVPQCDSPS------ 93
            :|...|...|:||:..|.|.:      |...:|:      |||....|||.|...|:.:
Human     6 LLGHAGDLWRFQILQTVFLSI------FAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDT 64

  Fly    94 -SVYEEDWLGFTIP-KKNSAWDDCHRYA-------------ANISDA-----ISGYTDPSGQYCL 138
             ::.::..|..:|| ..|...:.|.|:.             .|.|||     :.|:.
Human    65 GALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWV-------- 121

  Fly   139 KEYFTITSETCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGR 203
              |..|:..:            ||.||:.:.|:.:...|:...:...|..||..|||:.:||:||
Human   122 --YDRISFSS------------TIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGR 172

  Fly   204 RTMLAVAGSVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATII 268
            |.:|.......|::|...:|:..:.::....||......:|.....:|..|..  ..|..|..|.
Human   173 RFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWA--THRFQAMGIT 235

  Fly   269 TIFYALGEAF--LGFLASQVQHWRWLLRVLYAPAVLQILFL---WILPESVRWLLSQGAEEKASN 328
            ......|.||  |..||..::.|..|..|:..|..  ::||   |:| ||.|||:.....|:...
Human   236 LGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYF--VIFLTSSWLL-ESARWLIINNKPEEGLK 297

  Fly   329 VLRRAA-RINQRPLPEEQLNDLLTSNRQKLSQANESQYPIMRAVVFFSLRIANCC-------LCW 385
            .||:|| |...:...:....::|.|..:|..:|.:.:.|.:..:    |.:.|.|       ...
Human   298 ELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEM----LHMPNICKRISLLSFTR 358

  Fly   386 FTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGA 450
            |.:.:...||:|:..:||.|.:....|.|.:.:....:....:..:.||.|....|.|.|||:.|
Human   359 FANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLA 423

  Fly   451 SAAVPADNYAGSLALFLIGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTP 515
            ...||.:.......|..:|..|...:..:.:...:|:.||.:|...:.:.:....|...|||...
Human   424 IIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMM 488

  Fly   516 LLAKYYIYAPQILFATFALISGFLTLAFPETADKVLPTTIEEARDLNQAKRRSERSP 572
            :|:.|....|.|::..|..||||..|..|||.:|.|..||::.::    :|:..|.|
Human   489 ILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKN----ERKDPREP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	137/552 (25%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	103/395 (26%)
SLC22A9	NP_543142.2	Sugar_tr	11..527	CDD:331684	137/552 (25%)
SLC22A9	NP_543142.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..553		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153761
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940