DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_659105.2	Gene:	Slc22a7 / 108114	MGIID:	1859559	Length:	540	Species:	Mus musculus

Alignment Length:	554	Identity:	167/554 - (30%)
Similarity:	277/554 - (50%)	Gaps:	43/554 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEED-WLG 102
            :.:|.::|.||.:|:.|.|||.:|........:..:|.|:...|.|.:|  |:|:::..:| ||.
Mouse     4 EELLHKVGGFGPFQLRNLVLLALPRFLLPMHFLLPIFMAAVPAHHCALP--DAPANLSHQDLWLK 66

  Fly   103 FTIPKK-NSAWDDCHRYA-----ANISDAISGYT--DPSGQYCLKEYFTITSETCGRDFKFRDEE 159
            ..:|:: :.::..|.|:|     .|::.....|.  :|.|     |..|:   .|.:.:::...|
Mouse    67 THLPRETDGSFSSCLRFAYPQALPNVTLGTEVYNSGEPEG-----EPLTV---PCSQGWEYDRSE 123

  Fly   160 --KTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRS 222
              .||:||:.:.|:......:..|...:|..:|..:.||.:||:|||.:|.||...:..:|::.:
Mouse   124 FSSTIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAYVSTLALGLMSA 188

  Fly   223 LSSNYSMFLVFEFLDMAVGSTLFP-TAFLLAIEL--VGPKRRVAAATIITIFYALGEAFLGFLAS 284
            .|.||.||:...   |..||.|.. |..:|.:||  :..:.|..|..|.|.|:..|...|..:..
Mouse   189 ASVNYIMFVTTR---MLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTTFWTGGVLLLTLVGY 250

  Fly   285 QVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPE-----E 344
            .::.|||||.....|.|..|:.:|.:|||.||||:||..|:|...|...|::|.||:.|     |
Mouse   251 LIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPISEDSLSQE 315

  Fly   345 QLNDLLTSNRQKLSQANESQYPIMRAVVFFSLR-IANCC-LCWFTHTLIALGLSLNSVNLGGNKY 407
            .||.::|..|  :|| ..|...:.|.   ..|| ::.|| :.||.......||:|::..||...|
Mouse   316 ALNKVITMER--VSQ-RPSYLDLFRT---SQLRHVSLCCMMMWFGVNFSYYGLTLDASGLGLTVY 374

  Fly   408 TNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLA 472
            ...:|.|.:::|..:....::..||||.:....:|..|:..|.|..|.:|..:...||.:|||..
Mouse   375 QTQLLFGAVEVPSKITVFFLVRLVGRRLTEAGMLLATALTFGISLLVSSDTKSWITALVVIGKAF 439

  Fly   473 ITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISG 537
            ...:|...|.||||::||.:|.|.:...:::||:|:.|||...||...::..|::.:...:.::.
Mouse   440 SEAAFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLPKLAYGGISFLAA 504

  Fly   538 FLTLAFPETADKVLPTTIEEARDLNQAKRRSERS 571
            ...|..|||....||.||:   |:.:..|:.:||
Mouse   505 CTVLLLPETKKAQLPETIQ---DVERKGRKIDRS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	160/528 (30%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	124/392 (32%)
Slc22a7	NP_659105.2	2A0119	11..521	CDD:273328	160/528 (30%)
Slc22a7	NP_659105.2	MFS	146..511	CDD:119392	119/373 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020