DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7458 and slc22a7b.2

DIOPT Version :9

Sequence 1:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_001337343.1	Gene:	slc22a7b.2 / 100001838	ZFINID:	ZDB-GENE-030131-9391	Length:	556	Species:	Danio rerio

Alignment Length:	550	Identity:	138/550 - (25%)
Similarity:	243/550 - (44%)	Gaps:	52/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYV---FTASTVVHRCTVPQCDSPSSVYE----E 98
            :|..:..|||:|   .::||:..|........::   |.|:...|.|.:...| ...|:|    |
Zfish     6 LLSELNGFGRFQ---KMVLCINFLGRFSLGCHFLLGNFIAAIPSHHCNISSLD-VDGVFENLSQE 66

  Fly    99 DWLGFTIP-KKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSE----TCGRDFKFRDE 158
            :.|...:| :::.....||.           ::.|..|..:..  :.:|:    .|...:.|.:.
Zfish    67 ERLTVGVPAQEDGTPASCHM-----------FSHPQFQLLINS--SSSSDLPVVECQNGWHFDNS 118

  Fly   159 E--KTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIR 221
            .  .|::|::.:.|:......:..||..:|...|....|..:..:||:.||.|:..:....|:..
Zfish   119 TFISTLATQWDLVCDKRALGKLTTTIFFLGVMFGAAAFGSLSAMFGRKPMLLVSYILGMGFGLCS 183

  Fly   222 SLSSNYSMFLVFEFLD--MAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGF--L 282
            .|||:..||.|..|..  ...||.:..|  :|.:|.|..:.|.....|.::.:..|  |:||  :
Zfish   184 VLSSSLVMFAVLRFFSGFTITGSVIIST--VLNVEWVSIEHRKLVGVIDSLAWTFG--FMGFPVI 244

  Fly   283 ASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRP-----LP 342
            |..::.||||...:..|.|:.|:..|.:|||.|||:..|..:||...|::.|.:|.:.     :.
Zfish   245 AYFIRDWRWLTVAISLPNVISIITWWWVPESARWLIVNGKADKAHYYLKKCAAMNHKKEVTARIK 309

  Fly   343 EEQLNDLLTSNR--QKLSQANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGN 405
            .|.|:.::.::|  :|.|..:..:.|.||.:...:      .:.||:...:|.|:|.|....|.|
Zfish   310 PEDLSKIIVTDRGSRKYSYLDLVRTPKMRRLSLLT------GITWFSVATVAYGISFNITGFGLN 368

  Fly   406 KYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGK 470
            .|....:.|.|:||.......::|:.||..:...|:|...|....:..:|.:.......:.::||
Zfish   369 MYLTQFVYGAIEIPAKFCIYYLLDKFGRHVTQAGSLLFVGISFIINIFIPKEKTVIRTVIAVLGK 433

  Fly   471 LAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALI 535
            .....||..:..:|||::||.||...:...|.:.|.|..:||...|....:.|..|::....||.
Zfish   434 GCSATSFGTVILYTSELYPTVVRQNGMGYTSFIARFGVSVAPLILLSNDVWSYFSQVILCFLALS 498

  Fly   536 SGFLTLAFPETADKVLPTTIEEARDLNQAK 565
            :.|:....|||:.|.||.||::...:.:.|
Zfish   499 AAFVAYQLPETSGKCLPETIDDIEGIRKDK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	134/532 (25%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	104/393 (26%)
slc22a7b.2	XP_001337343.1	2A0119	12..517	CDD:273328	134/531 (25%)
slc22a7b.2	XP_001337343.1	MFS	140..504	CDD:119392	101/373 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010